Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tim D. Spector"'
Autor:
Alex J. MacGregor, Alireza Moayyeri, Aedin Cassidy, Jane Skinner, Ailsa A Welch, Tim D. Spector
Publikováno v:
Osteoporosis International. 24:1899-1908
Conservation of muscle mass is important for fall and fracture prevention but further understanding of the causes of age-related muscle loss is required. This study found a more alkaline diet was positively associated with muscle mass in women sugges
Autor:
Elaine M. Dennison, William D. Leslie, Hou-Feng Zheng, Braxton D. Mitchell, Mattias Lorentzon, Richard Eastell, Richard L. Prince, Scott Wilson, Geoffrey C. Nicholson, Eugene V. McCloskey, Ulrika Pettersson, Patrick Danoy, Martin Ladouceur, Emma L. Duncan, Paul Leo, Matthew A. Brown, Graeme Jones, Joel Eriksson, John A. Eisman, Lanr Reid, Ulrica Bergström, David Goltzman, Claes Ohlsson, Elizabeth A. Streeten, Philip N. Sambrook, Laura M. Yerges-Armstrong, Jeff Liu, J. Brent Richards, Yongjun Xiao, Liesbeth Vandenput, Robert Brommage, Tim D. Spector
Publikováno v:
Osteoporosis International. 23:401-417
WNT16 is associated with bone mineral density, osteoporotic fracture and bone strength : a large-scale meta-analysis of genomewide association studies
Autor:
Scott Wilson, Shelby Chew, Richard L. Prince, Benjamin H. Mullin, Tim D. Spector, Joshua R. Lewis
Publikováno v:
Osteoporosis International. 22:1981-1986
Previously, homozygous deletion of the UGT2B17 gene has shown association with hip fracture. Using a high-throughput qRT-PCR assay, we genotyped UGT2B17 copy number variation (CNV) in 1,347 elderly Caucasian women and examined for effects on bone phe
Autor:
D. Felsenberg, Olivier Bruyère, Jean-Yves Reginster, Julien Collette, Tim D. Spector, JM Kaufman, Steven Boonen, M. Diaz-Curiel, Roman S. Lorenc
Publikováno v:
Osteoporosis International
Summary Osteoporotic post-menopausal women patients in two randomised trials comparing the anti-fracture efficacy of strontium ranelate with placebo were separated into tertiles according to their baseline levels of biochemical markers of bone format
Publikováno v:
Osteoporosis International. 15:367-374
Osteoporosis is a highly prevalent but preventable disease and, as such, it is important that there are appropriate diagnostic criteria to identify those at risk of low trauma fracture. In 1994 the World Health Organization (WHO) introduced definitio
Publikováno v:
Osteoporosis International. 12:406-411
The aim of the study was to determine whether the genetic variance in bone mineral density (BMD) and calcaneal ultrasound differs in pre- and postmenopausal women and to establish whether the genes operating before the menopause are the same as those
Publikováno v:
Osteoporosis International. 6:399-406
A number of recent studies have suggested that non-invasive measures of bone turnover are associated with bone loss at the forearm in postmenopausal women. Whether bone turnover markers are predictive of bone loss from the clinically important sites
Publikováno v:
Osteoporosis International. 6:334-337
Quantitative ultrasound of the calcaneus and hip axis length are independent predictors of hip fracture and have a major genetic component. Polymorphisms of the vitamin D receptor gene (VDR) have been associated with variations in bone density in a n
Autor:
Tim D. Spector, R W Keen
Publikováno v:
Osteoporosis International. 6:16-20
The incidence of osteoporosis has increased over the last 30 years, and is expected to continue to increase into the next century. Drug treatment for this condition has evolved with an understanding of the disordered processes that underlie the devel
Publikováno v:
Osteoporosis International. 2:219-224
It is now accepted that unopposed oestrogen therapy reduces osteoporotic fractures by about 50%. Although current regimes with added progestogens are thought to act similarly to unopposed oestrogens, no study has yet demonstrated an effect on fractur