Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Tim D. Spector"'
Differences between race and sex in measures of hip morphology: a population-based comparative study
Autor:
Amanda E. Nelson, David J. Hunter, Michael C. Nevitt, Katherine Edwards, C.P. Arden, Nigel K Arden, K M Leyland, Tim D. Spector, Joanne M. Jordan, Maria T. Sanchez-Santos
Publikováno v:
Osteoarthritis and Cartilage.
Objective: This paper aims to (i) identify differences in measures of hip morphology between four racial groups using anteroposterior (AP) hip x-rays, and (ii) examine whether these differences vary by sex. Methods: 912 hip x-rays (456 individuals) f
Autor:
D Hart, Jeffrey B. Driban, Grace H. Lo, Bing Lu, Timothy E. McAlindon, Nigel K Arden, Raveendhara R. Bannuru, Charles B. Eaton, Tim D. Spector
Publikováno v:
Osteoarthritis and Cartilage. 27:S250-S251
Autor:
S.M.A. Bierma-Zeinstra, Anne-Christine Bay-Jensen, A. Hofman, J.B. van Meurs, Ana M. Valdes, Tim D. Spector, E Chassaing, Eline Slagboom, Ingrid Meulenbelt, A.G. Uitterlinden, Margreet Kloppenburg, Morten A. Karsdal, Herman M. Kroon, D Hart, Nigel K Arden
Publikováno v:
Osteoarthritis and Cartilage, 22(5), 683-689
Osteoarthritis and Cartilage, 22(5), 683-689. W.B. Saunders
Osteoarthritis and Cartilage, 22(5), 683-689. W.B. Saunders
Objective: To evaluate the role of three cartilage-derived biomarkers on osteoarthritis (OA): urinary C-terminal telopeptide (uCTX-II), serum cartilage oligomeric protein (sCOMP), and serum MMP degraded type II collagen (sC2M). Subjects and methods:
Autor:
D. Karasikl, Richard M. Aspden, Rebecca J. Barr, Steve Cummings, Nancy E Lane, B.G. Faber, Claudiu V. Giuraniuc, Douglas P. Kiel, Scott Wilson, Jonathan H Tobias, Daniel S. Evans, B. H. Mullins, Debbie A Lawlor, F. K. Kamanu, B. Richards, Jennifer S. Gregory, Denis Baird, Lavinia Paternoster, Thomas J. Beck, Frances M K Williams, David M. Evans, Fiona R. Saunders, Tim D. Spector, Eric S. Orwoll
Publikováno v:
Osteoarthritis and Cartilage. 26:S157
Autor:
Cyrus Cooper, David Hart, Enrico Pola, Tim D. Spector, Sally Doherty, Kalle Kisand, Nigel K Arden, Irina Kerna, Weiya Zhang, F. O'Neil, Ana M. Valdes, Kenneth Muir, Rose A. Maciewicz, Michael Doherty, Ann Tamm
Publikováno v:
Osteoarthritis and Cartilage; Vol 18
OBJECTIVE: Interleukin-6 is a pro-inflammatory cytokine involved in the pathogenesis of osteoarthritis (OA). We investigated the role of two single nucleotide polymorphisms (SNPs) mapping to the promoter of the IL-6 gene on genetic susceptibility to
Autor:
Kenneth D. Brandt, Eric Vignon, David J. Hunter, S.A. Mazzuca, Jean-Francis Maillefert, M. P. Hellio-Le Graverand, Margreet Kloppenburg, Nancy E Lane, Paul Ornetti, Tim D. Spector, Marc C. Hochberg, Maxime Dougados, G. Utard-Wlerick
Publikováno v:
Osteoarthritis and Cartilage. 17(7):856-863
Summary Background Joint space width (JSW) evaluated in millimeters on plain X-rays is the currently optimal recognized technique to evaluate osteoarthritis (OA) structural progression. Data obtained can be presented at the group level (e.g., mean±s
Autor:
A.G. Uitterlinden, Mila Jhamai, S.M.A. Bierma-Zeinstra, Tim D. Spector, A. Hofman, Ana M. Valdes, J M Kerkhof, D Hart, Huib A.P. Pols, J.B. van Meurs, Fernando Rivadeneira
Publikováno v:
Osteoarthritis and Cartilage, 16(10), 1141-1149. W.B. Saunders
Summary Objective To examine the association of genetic variation in key players in the Wnt signaling pathway with aspects of osteoarthritis (OA) in two population-based cohort studies: the Rotterdam Study and the Chingford Study. Methods Radiographi
Autor:
Kourosh R. Ahmadi, David J. Hunter, Tim D. Spector, Guangju Zhai, Bernet S. Kato, Feng Zhang, D Hart
Publikováno v:
Osteoarthritis and Cartilage. 15(6):624-629
Summary Objective Osteoarthritis (OA) is a common complex disease with strong heritable components. In this study, we investigated the association between four putatively functional genetic variants in KLOTHO gene, a strong ageing-related gene, and h
Autor:
Jeffrey L. Bidwell, J.R. Sandy, M.J. Perry, J. Gidley, Jason P. Mansell, Michael Doherty, Christopher J. Elson, A J P Smith, Tim D. Spector, John R. Kirwan
Publikováno v:
Osteoarthritis and Cartilage. 13(7):608-613
Summary Objective Several genome-wide scans have revealed an osteoarthritis (OA)-susceptibility locus on chromosome 11q in close proximity to the low-density lipoprotein receptor-related protein 5 ( LRP5 ) gene. The regulation of bone mass is under t
Autor:
Eric Vignon, Karel Pavelka, Stefan Lohmander, Roy D. Altman, Daniel A. Bloch, Maxime Dougados, Marc C. Hochberg, Tim D. Spector
Publikováno v:
Osteoarthritis and Cartilage. 12(7):515-524
Objective To outline the best available method of measurement for detecting progression of osteoarthritis (OA) of the hip especially in therapeutic trials. Method A Medline search of articles related to progression of hip OA was performed. A group of