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Publikováno v:
ORL. 81:92-100
Background/Aims: Mitochondrial DNA (mtDNA) is sensitive to oxidative damage during aging, which can result in mtDNA mutations. A previous study reported that a 3,860-bp mtDNA deletion, similar to a 4,977-bp mtDNA deletion in humans, is also common oc
Autor:
Xiangrui Guo, Lei Xu, Haibo Wang, Jianfeng Li, Xianmin Wu, Xiaofei Li, Chong Ma, Jing Cai, Yuechen Han
Publikováno v:
ORL. 81:202-214
Cisplatin is an anti-cancer drug that causes oxotoxic side effects such as impairment of inner ear function and hearing loss. We aimed to investigate the effects of allicin against cisplatin-induced stria vascularis damage in mice, and to clarify the
Autor:
Batista Ama, de Freitas Mr, Brito Gac, Brito Ynf, Soares Pmg, Martins Cds, Ribeiro Ra, Martins Mjb
Publikováno v:
ORL. 79:336-346
Background/Aims: Cisplatin is a chemotherapeutic agent. The use of remote ischemic preconditioning (RIPC) was proposed after the observation that ischemic preconditioning of a cardiac vascular area could protect another completely distinctly. Methods
Publikováno v:
ORL. 75:37-45
Objective: To evaluate the differences in clinical features and expression of cytokine thymic stromal lymphopoetin (TSLP) and its receptors in patients with eosinophilic and non-eosinophilic chronic rhinosinusitis (ECRS and NECRS). Method: 36 ECRS pa
Autor:
Dimitrios Koutsimpelas, Roland H. Stauber, B. Adryan, Irene Schmidtmann, Kai Fruth, Jürgen Brieger, K. Frauenknecht, R. Yetis, Haralampos Gouveris, M. Bjelopavlovic, Ulf-Rüdiger Heinrich, Wolf J. Mann
Publikováno v:
ORL. 74:330-338
Background/Aims: The molecular mechanisms downstream of mutated neurofibromatosis type 2 (NF2) gene resulting in the growth and development of vestibular schwannoma (VS) are controversial. Several lines of evidence suggest the involvement of the vasc
Autor:
Richard R. Gacek
Publikováno v:
ORL. 74:22-27
Objective: To demonstrate the organization of the spiral ganglion in the mammalian species. Methods: Temporal bone (TB) specimens from man (n = 2), monkey (n = 2), lion (n = 2) and cat (n = 20) were stained, decalcified and dissected according to the
Publikováno v:
ORL. 74:16-21
Objective: Reversion-inducing cysteine-rich protein with kazal motifs (RECK) may negatively regulate matrix metalloproteinase 9 (MMP9) activity and suppress tumor invasion and metastasis. The aim of this study was to investigate whether RECK and MMP
Publikováno v:
ORL. 69:251-255
Cholesteatomas show histomorphological features like papillary growth and koilocytosis, which are characteristic of lesions induced by human papillomaviruses (HPV). Two previous studies investigating the possible role of HPV in the development of cho
Autor:
Rudolf Häusler, Marco Caversaccio
Publikováno v:
ORL. 68:266-269
To assess the long-term results of double bicanalicular silicone tubes in canalicular (presaccal) stenosis of the nasolacrimal duct system, a retrospective follow-up was performed on patients operated between 1992 and 2002. Forty-five patients were i
Autor:
Heinz Schmidberger, Olivier Pradier, Hans Christiansen, Petra Ambrosch, Martina Kron, Clemens F. Hess
Publikováno v:
ORL. 66:325-331
Background: Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. The purpose of this study was to evaluate the efficacy and toxicity of split-course rad