Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ashok K. Gupta"'
Autor:
David M. Barnes, Jufang Barkalow, Yong Chen, Francis A. J. Kerdesky, John E. Hengeveld, Anthony R. Haight, Bryan Macri, Ashok K. Gupta, Agnes Pal, Brian J. Kotecki
Publikováno v:
Organic Process Research & Development. 13:225-229
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorpo
Autor:
Ashok K. Gupta, Yu-Ming Pu, Ashok V. Bhatia, Daniel J. Plata, Marlon Cowart, Timothy A. Grieme, Yi-Yin Ku
Publikováno v:
Organic Process Research & Development. 9:45-50
A facile and scaleable synthesis of a potent and selective histamine H3 receptor antagonist, ABT-239 (1), was developed starting from commercially available 4‘-hydroxy-biphenyl-4-carbonitrile (2). The synthesis comprised four chemical steps and a s
Autor:
Michael G. Fickes, Zhenping Tian, Shyamal Parekh, Todd S. Mcdermott, Sou-Jen Chang, Steven J. Wittenberger, Ashok K. Gupta, Dilinie P. Fernando, David R. Hill
Publikováno v:
Organic Process Research & Development. 6:329-335
A process for the preparation of matrix metalloproteinase inhibitor ABT-518 has been developed. Significant improvements have been made to the first generation synthesis and are described here. The new process is very robust and efficient; multikilog
Autor:
Pulla Reddy Singam, Jufang Barkalow, Gary Callen, b Mukund Chorghade, c and Howard Foote, Michael Cain, a Roger Koops, Richard Pariza d, David Brown, Patel Ketan M, Subhash R. Patel, Ashok K. Gupta, Mahendra N. Deshpande
Publikováno v:
Organic Process Research & Development. 2:351-356
A scalable process for the novel antidepressant ABT-200, starting with 5,6-methylenedioxy-1-tetralone, is described. The new process improves the scale-up and safety concerns associated with the previously employed route to ABT-200. The scalable proc