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of 42
pro vyhledávání: ''
Autor:
Betty Pakzad, Ketan Patel, Mark C. Herzberg, Deepak Kademani, Ali Khammanivong, Ioannis G. Koutlas, Chris Malz, Prokopios P. Argyris, Zachary M. Slama
Publikováno v:
Oral Oncol
Objectives Calprotectin (S100A8/A9) appears to function as a tumor suppressor in head and neck squamous cell carcinoma (HNSCC) and expression in the carcinoma cells and patient survival rates are directly related. We seek to characterize the suppress
Autor:
Marcin Kowanetz, Lai Kwan Chan, Oscar S.H. Chan, Rebecca M.W. Yeung, Hartmut Koeppen, Christoph Mancao, Lukas C. Amler, Haiyan Wu, Wai Tong Ng
Publikováno v:
Oral oncology. 67
Objectives Locally recurrent or metastatic nasopharyngeal cancer (NPC) remains an important challenge, with more effective and durable therapeutic options needed. Cancer immunotherapy, and in particular therapies that target the PD-L1/PD-1 immune che
Autor:
S.I. Collins, Hazel Williams, Hanna M. Romanska, Fedor Berditchevski, S. Parmar, Piotr Potemski
Publikováno v:
Oral Oncology. 49:224-229
Summary Objectives The study aimed to assess the role of CD151-integrin α3β1 (INGA3) complex as a potential prognostic indicator in OSCC and to examine whether mapping of its expression in the invasive front separately from that in the rest of the
Autor:
Athanassios Argiris, William E. Gooding, Maria L. Freilino, Sufi M. Thomas, Jennifer R. Grandis, Neil D. Gross, Howard S. Moskowitz, Robert L. Ferris
Publikováno v:
Oral oncology, vol 48, iss 11
Summary Objective Targeting the epidermal growth factor receptor (EGFR) using the tyrosine kinase inhibitor (TKI) erlotinib has demonstrated activity in aerodigestive tract malignancies. Co-targeting of the G-protein-coupled receptor cyclooxygenase (
Autor:
Hye Sung Won, Min-Sik Kim, Sang Hoon Chun, Chan Kwon Jung, Yeon-Sil Kim, Dong-Il Sun, Jin-Hyoung Kang
Publikováno v:
Oral Oncology. 48:985-990
Summary Objectives The aims of this study were to evaluate the expression of EGFR, PI3K, Akt, mTOR, and PTEN in the oral cavity and oropharyngeal cancers, and to investigate their clinical significance as prognostic markers. Materials and methods One
Publikováno v:
Oral Oncology. 47:1117-1121
Transforming growth factor (TGF)-β1, the most abundant isoform of TGF-β have been implicated in various stages of carcinogenesis such as epithelial to mesenchymal transition, enhanced expression of metalloproteases, down-regulation of cellular adhe
Autor:
Saara Kantola, Kalle Alanen, Ibrahim O. Bello, Marilena Vered, Ran Yahalom, Dan Dayan, Tuula Salo, Esa Läärä, Alex Dobriyan, Pentti Nieminen
Publikováno v:
Oral Oncology. 47:33-38
Mobile tongue squamous cell carcinoma (MTSCC) is known for its strong propensity for regional metastasis and poor patient survival despite aggressive treatment, thus calling for new and reliable markers for predicting prognosis and guiding therapeuti
Autor:
Luiz Paulo Kowalski, Inês Nobuko Nishimoto, Dirce Maria Carraro, Fernando Augusto Soares, Sabrina Daniela da Silva, Isabela Werneck da Cunha, Edgard Graner
Publikováno v:
Oral Oncology. 45:e134-e139
Overexpression of fatty acid synthase (FASN) and ErbB2 has been described in oral squamous cell carcinomas (OSCC). FASN is the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids and its expression can be regulated by ErbB2.
Autor:
Alexander Berndt, Hartwig Kosmehl, Katrin Kromeyer-Hauschild, Stephan Schwarz, Regine Dahse, Oliver Driemel
Publikováno v:
Oral Oncology. 45:826-829
Salivary gland carcinomas (SGC) are rare cancers with poor prognosis and limited response to conventional chemotherapy. New strategies based on molecular targeted therapy are needed and the EGFR signaling cascade is considered a possible key pathway
Autor:
Terry Jones, Timothy R. Helliwell, David Husband, John E. Fenton, Andrew S. Jones, Mark Rafferty
Publikováno v:
Oral Oncology. 44:975-981
Cell cycle modulators are important in carcinogenesis and may be of prognostic and therapeutic relevance. This study has examined the influence of the proliferation index (Ki-67) and immunocytochemical expression of epidermal growth factor receptor (