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Autor:
Sunil Badve, Sumanth Vasista, Sukhmani K. Padda, Heather A. Wakelee, Jessica A. Hellyer, Kabya Basu, Yesim Gökmen-Polar, Neeraj Kumar Singh, Ansu Kumar
Publikováno v:
Oncotarget
Further characterization of thymic epithelial tumors (TETs) is needed. Genomic information from 102 evaluable TETs from The Cancer Genome Atlas (TCGA) dataset and from the IU-TAB-1 cell line (type AB thymoma) underwent clustering analysis to identify
Autor:
Juha Kononen, Greg Wells, Zoi Lygerou, Nibal Badra Fajardo, Juha Rantala, Rami Mäkelä, Olle Sangfelt, Ville Härmä
Publikováno v:
Oncotarget
Cutaneous apocrine carcinoma is an extreme rare malignancy derived from a sweat gland. Histologically sweat gland cancers resemble metastatic mammary apocrine carcinomas, but the genetic landscape remains poorly understood. Here, we report a rare met
Autor:
Milagros Suarez, Leonidas C. Platanias, Shira Dinner, Elizabeth A. Eklund, Alain Mina, Ewa M. Kosciuczuk, Jessica K. Altman, Gavin T. Blyth, Elspeth M. Beauchamp, Blazej Dolniak, Diana Saleiro
Publikováno v:
Oncotarget
The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for acute myeloid leukemia (AML). We evaluated the therapeutic potential of the highly-selective MNK1/2 inhibitor Tomivosertib on AML cells. Tomiv
Publikováno v:
Oncotarget
Retinoblastoma is the most common pediatric intraocular malignant tumor. While retinoblastoma initiation is triggered by the inactivation of both alleles of the retinoblastoma tumor suppressor gene (RB1) in the developing retina, tumor progression re
Autor:
Akhilesh K. Gaharwar, Steven J. Werden, Nathalie Sphyris, Geraldine V. Vijay, Cody King, Naoyuki Miura, Jonathan Hoar, Tapasree Roy Sarkar
Publikováno v:
Oncotarget
Hypoxia stimulates neoangiogenesis, promoting tumor outgrowth, and triggers the epithelial-mesenchymal transition (EMT), which bestows cells with mesenchymal traits and multi-lineage differentiation potential. Here, we investigated whether EMT can co
Autor:
Anna C. Reisetter, Sadanandan E. Velu, Jordan L. Kohlmeyer, Mariah R. Leidinger, Georgina K. Ofori-Amanfo, Dawn E. Quelle, Parmanand Ahirwar, Chandni Desai, Khadijeh Jahanseir, Jon Thomason, Patrick Breheny, Karen J. Fritchie, Munir R. Tanas
Publikováno v:
Oncotarget
Additional prognostic and therapeutic biomarkers effective across different histological types of sarcoma are needed. Herein we evaluate expression of TAZ and YAP, the p53-MDM2 axis, and RABL6A, a novel oncoprotein with potential ties to both pathway
Autor:
Leila Zemoura, Damien Treguer, Nicolas Girard, Marie Brevet, A. Chapelier, Didier Decaudin, Olivier Deas, Sophie Chateau-Joubert, Stefano Cairo, Rania El Botty, Sergio Roman-Roman, André Nicolas, Didier Meseure, Ivan Bièche, Sophie Vacher, Ludmilla de Plater, Elodie Montaudon, Elisabetta Marangoni, Catherine Daniel, Fariba Nemati, Adnan Naguez, Alain Livartowski
Publikováno v:
Oncotarget. 12:859-872
Significant rational is available for specific targeting of PI3K/AKT/mTOR pathway in the treatment of non-small cell lung cancer (NSCLC). However, almost all clinical trials that have evaluated Pi3K pathway-based monotherapies/combinations did not ob
Autor:
Viswanathan Palanisamy, Philip H. Howe, Harinarayanan Janakiraman, Radhika Gudi, Chenthamarakshan Vasu
Publikováno v:
Oncotarget
Higher epidermal growth factor receptor (EGFR) signaling can contribute to tumor metastasis and resistance to therapies in oral squamous cell carcinoma (OSCC). EGFR signaling can promote epithelial-mesenchymal transition (EMT) in OSCC. EMT is a proce
Publikováno v:
Oncotarget
Pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of pancreatic cancer, has one of the highest case fatality rates of all known solid malignancies. Over the past decade, several landmark studies have established mutations
Autor:
Penelope J. Duerksen-Hughes, Lennox Chitsike, Chung-Hsiang Yuan, Kristopher E. Boyle, Anuradha Roy
Publikováno v:
Oncotarget. 12:549-561
The incidence of human papillomavirus-positive head and neck squamous cell carcinoma (HPV+-HNSCC) has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV. The etiology of HPV+-HNSCC is linked to expr