Zobrazeno 1 - 10
of 75
pro vyhledávání: '"11"'
Publikováno v:
Oncology Reports
Lysine methyltransferase 2A (KMT2A, also known as MLL) translocations (MLL-t) are frequently associated with mutations in RAS pathway genes in acute myeloid leukemia (AML). Previous findings with a mouse model showed that cooperation of MLL/AF10 with
Publikováno v:
Oncology Reports
Non-small cell lung cancer (NSCLC) accounts for >80% of lung cancer cases and is the leading cause of cancer-associated mortality worldwide. Propofol is an anesthetic drug frequently used during tumor resection. It is also known to exert inhibitory e
BH3 profiling discriminates the anti-apoptotic status of 5-fluorouracil-resistant colon cancer cells
Autor:
Koji Miyanishi, Tomohiro Kubo, Yohei Arihara, Kazuyuki Murase, Kazuma Ishikawa, Masayoshi Kobune, Yutaka Kawano, Kohichi Takada, Junji Kato
Publikováno v:
Oncology Reports
5‑Fluorouracil (5‑FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting in
Autor:
Yuan Huang, Xiaoai Lv, Ping Huang, Jian Huang, Xiying Shao, Bei Wang, Yabing Zheng, Xiaojia Wang, Lei Shi, Zhanhong Chen
Publikováno v:
Oncology Reports. 35:683-690
MicroRNAs are emerging as critical regulators of the initiation and progression of multiple types of human cancers, including breast cancer. In the present study, the expression of miR-181b in breast cancer patient serum and breast cancer cell lines
Publikováno v:
Oncology reports. 40(2)
Osteosarcoma (OS) is the most common primary malignant bone tumor worldwide, primarily affecting children and adolescents. The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that is activated by its co‑activator Cdc20 during the
Publikováno v:
Oncology Reports.
Cisplatin resistance is a major cause of chemotherapeutic failure in lung cancer patients. Unraveling the molecular mechanisms underlying cisplatin (CDDP) resistance is important in lung cancer therapeutics. To explore the role of Src homology phosph
Autor:
Ludmila Gorunova, Lisbeth Haugom, Sverre Heim, Anne Mette Eibak, Francesca Micci, Ivar P. Gladhaug, Sven-Petter Haugvik
Publikováno v:
Oncology Reports
The pathogenesis of sporadic pancreatic neuroendocrine neoplasms (PNENs) is poorly understood. To gain insight into the genetic mechanisms underlying this tumor entity, we performed genome-wide screening of 16 surgical specimens from 15 patients with
Publikováno v:
Oncology Reports
Expression of Src homology phosphotyrosine phosphatase 2 (SHP2) has been observed in human breast cancer. SHP2 is known to promote cell migration and invasiveness. However, the pathophysiologic role of SHP2 and its relevance to tumorigenesis are stil
Autor:
Eric T. Wong, Susan O'brien
Publikováno v:
Oncology reports. 5(2)
Refractory anemia with excess blasts in transformation (RAEB-T) is a pre-leukemic syndrome that can progress to acute myelogenous leukemia (AML). Although leptomeningeal disease in AML is rare and it is commonly associated with specific cytogenetic a
Publikováno v:
Oncology Reports.
MicroRNAs (miRNAs) are emerging as a class of small regulatory RNAs whose alterations are implicated in the initiation and progression of human cancers. Our study showed that miR-25 was highly expressed both in clinical ovarian cancer samples and cel