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Autor:
Fanyi Meng, Jiaheng Zhou, Dan Xu, Changxin Yin, Zhongxin Zheng, Guopan Yu, Qifa Liu, Fuqun Wu, Xuejie Jiang, Ling Jiang
Publikováno v:
Oncology Reports
Gene mutations play a critical role in leukemogenesis of AML1-ETO-positive acute myeloid leukemia (AE-AML). Nevertheless, gene mutation profile in this subtype leukemia remains unclear, and their clinical effect might be underestimated. In this study
Publikováno v:
Oncology Reports. 34:2365-2374
Interleukin-17A-producing T cells (IL-17A+ T) (IL-17A+CD4+ Th17, IL-17A+CD8+ Tc17 and IL-17A+ γδT17 cells) and associated cytokines (IL-17A, IL-23 and IL-1β) play crucial roles in inflammation-associated diseases, such as infection, autoimmunity a
Autor:
Dawo Liu, Mingzi Tan, Song Gao, Bei Lin, Na Gao, Limei Yan, Yingying Hao, Juanjuan Liu, Liancheng Zhu
Publikováno v:
Oncology Reports
FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated carbohydrate antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to proliferation, invasion and prognosis in malignant epithelial tumors. A c-
Autor:
Masahito Nakano, Manabu Satani, Shuji Sumie, Shingo Yamada, Tatsuo Kanda, Fumio Imazeki, Shingo Nakamoto, Tatsuyuki Kakuma, Ryoko Kuromatsu, Osamu Yokosuka, Takumi Kawaguchi, Atsushi Kawaguchi, Takuji Torimura, Michio Sata
Publikováno v:
Oncology Reports. 30:2049-2055
Although overt hepatitis B virus (HBV) infec- tion promotes the onset of hepatocellular carcinoma (HCC) in hepatitis C virus (HCV)-infected patients, the effect of occult HBV infection remains unclear. The aim of this study was to investigate the eff
Autor:
Takeshi Machida, Yoshihisa Koyama, Shinji Ohki, Masahiko Shibata, Izumi Nakamura, Tatsuo Shimura, Shinichi Suzuki, Kenji Gonda, Toru Ohtake, Hitoshi Ohto, Seiichi Takenoshita
Publikováno v:
Oncology Reports. 28:453-458
Recent studies have identified myeloid-derived suppressor cells (MDSCs) that are potent suppressors of tumor immunity and therefore a significant impediment to cancer immunotherapy. It has been reported that MDSCs are generated by malignant diseases
Autor:
Ch. Touloumis, Eleni Katsantoni, P. Ntounas, Anastasia Filippopoulou, Emmanouil Rizos, Nikolaos Siafakas, Anastasia N. Kastania, Anna Koumarianou, Vassilis Zoumpourlis
Publikováno v:
Oncology reports. 28(6)
Previous studies have suggested that schizophrenia is associ-ated with a reduced risk of cancer. Genes that are involved in cell cycle regulation seem to have additional functions in post-mitotic neurons involved in neuronal migration and synaptic pl
Publikováno v:
Oncology reports. 28(3)
Clinical outcome of diffuse large B-cell lymphoma (DLBCL) patients with hepatitis C virus (HCV) infection in the rituximab era remains unclear. The aim of the present study was to compare the clinical outcome, treatment response and hepatotoxicity in
Publikováno v:
Oncology Reports. 24
Rho GDP dissociation inhibitors (RhoGDIs) are important regulators of the GTP hydrolase activity and biological functions of Rho GTPases. RhoGDI2 has been shown to be a metastasis suppressor in bladder cancer and several other cancers. However, the u
Autor:
Kenji Sumi, Masatsugu Hiraki, Yuji Nakafusa, Jun Nakamura, Kohji Miyazaki, Hirokazu Noshiro, Yoshihiko Kitajima, Kazuyoshi Hashiguchi
Publikováno v:
Oncology reports. 23(1)
Aberrant gene methylation is frequently observed in various cancers and plays an important role in carcinogenesis, cancer progression and drug responsiveness. The aim of this study is to identify colorectal cancer specific gene methylation determinin
Autor:
Qiuping Zhang, Mei Li, Rachel W. Li, Shen Lu, Zhimin Liu, Luming Zhou, Shihua Cheng, Shichang Yue, Lina Liu, Paul N. Smith
Publikováno v:
Oncology Reports. 22
KRAS mutation is closely associated to carcinogenesis and prognosis of non-small cell lung cancer (NSCLC). Detection of KRAS mutation can also be used to select NSCLC patients for drug targeting with EGFR tyrosine kinase inhibitors. Data regarding th