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Autor:
Nikolaos Ioannou, Said Abdullah Khelwatty, Helmout Modjtahedi, Satvinder Mudan, Angus G. Dalgleish, Tanzeel Khan, Alan M. Seddon
Publikováno v:
Oncology Reports
Pancreatic cancer is one of the most aggressive, heterogeneous and fatal type of human cancers for which more effective therapeutic agents are urgently needed. Here, we investigated the sensitivity of a panel of seven human pancreatic cancer cell lin
Autor:
Kazuaki Takabe, Takafumi Shima, Kazuhiro Yoshida, Jun Arima, Sang-Woong Lee, Kohei Taniguchi, Kazuhisa Uchiyama, Yosuke Inomata, Yoshihisa Tokumaru
Publikováno v:
Oncology Reports
Imatinib mesylate (imatinib) is the primary agent of choice used to treat gastrointestinal stromal tumors (GIST). However, drug resistance to imatinib poses a major obstacle to treatment efficacy. In addition, the relationship between imatinib resist
Autor:
Yuko Shirono, Masaki Murata, Vladimir Bilim, Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Yoshihiko Tomita, Kazuhide Saito, Andrey Ugolkov
Publikováno v:
Oncology Reports
The selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient-derived tumor organoid (TO) cult
Publikováno v:
Oncology Reports. 46
Molecular-targeted therapy has shown promise as a treatment for advanced osteosarcoma (OS). Sorafenib (SOR), a multikinase inhibitor, is the approved systemic drug of choice for OS, but has demonstrated limited benefits due to its toxicity and other
Publikováno v:
Oncology Reports. 46
Hepatocellular carcinoma (HCC) is one of the most aggressive and lethal malignancies with a rising incidence, and is characterized by rapid progression, frequent metastasis, late diagnosis, high postoperative recurrence and poor prognosis. Therefore,
Autor:
Jianzhuang Ren, Xuhua Duan, Zhao Guorui, Xinwei Han, Ju Shuguang, Hao Li, Wang Manzhou, Pengfei Chen
Publikováno v:
Oncology Reports. 46
The aim of the present study was to investigate the arsenic trioxide (ATO) loading/releasing efficiency of CalliSphere beads (CBs), as well as the in vitro anticancer activity, in vivo pharmacokinetics, treatment efficacy and safety of ATO-eluting CB
Autor:
Yanying Zhong, Fang Xu, Fuyin Le, Qi Zuo, Xingwu Wu, Jiao Cheng, Xiali Zhang, Buzhen Tan, Chen Luo
Publikováno v:
Oncology Reports
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide (TPL) exhibits antic
Publikováno v:
Oncology Reports
As the major component of the tumor matrix, collagen greatly influences tumor invasion and prognosis. The present study compared the remodeling of collagen and collagenase in 56 patients with colorectal cancer (CRC) using Sirius red stain and immunoh
Curcumin enhances anti‑cancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells
Publikováno v:
Oncology Reports
Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti‑cancer drug in various human cancers. However, the effects of combination treatment of curcumin with gemcitabine or docetaxel on
Autor:
Noelia Puente‑Moncada, Maria Turos‑Cabal, Carmen Rodríguez, Cristina Duarte‑Olivenza, Ana M. Sánchez‑Sánchez, Federico Herrera, Jezabel Rodriguez‑Blanco, Isaac Antolín, Vanesa Martín
Publikováno v:
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The FMS‑like tyrosine kinase 3 internal tandem duplication (FLT3‑ITD) mutation represents the most frequent genetic alteration in acute myeloid leukemia (AML) and is associated with poor prognosis. The mutation promotes cancer cell survival and p