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Autor:
Yuko Shirono, Masaki Murata, Vladimir Bilim, Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Yoshihiko Tomita, Kazuhide Saito, Andrey Ugolkov
Publikováno v:
Oncology Reports
The selection of effective therapeutic agents is critical for improving the survival of patients with renal cell carcinoma (RCC). The aim of the present study was to develop an ex vivo drug testing assay using patient-derived tumor organoid (TO) cult
Publikováno v:
Oncology Reports. 46
Hepatocellular carcinoma (HCC) is one of the most aggressive and lethal malignancies with a rising incidence, and is characterized by rapid progression, frequent metastasis, late diagnosis, high postoperative recurrence and poor prognosis. Therefore,
Autor:
Jianzhuang Ren, Xuhua Duan, Zhao Guorui, Xinwei Han, Ju Shuguang, Hao Li, Wang Manzhou, Pengfei Chen
Publikováno v:
Oncology Reports. 46
The aim of the present study was to investigate the arsenic trioxide (ATO) loading/releasing efficiency of CalliSphere beads (CBs), as well as the in vitro anticancer activity, in vivo pharmacokinetics, treatment efficacy and safety of ATO-eluting CB
Autor:
Yanying Zhong, Fang Xu, Fuyin Le, Qi Zuo, Xingwu Wu, Jiao Cheng, Xiali Zhang, Buzhen Tan, Chen Luo
Publikováno v:
Oncology Reports
Advanced and recurrent ovarian cancer has a poor prognosis and is frequently resistant to numerous therapeutics; thus, safe and effective drugs are needed to combat this disease. Previous studies have demonstrated that triptolide (TPL) exhibits antic
Publikováno v:
Oncology Reports
As the major component of the tumor matrix, collagen greatly influences tumor invasion and prognosis. The present study compared the remodeling of collagen and collagenase in 56 patients with colorectal cancer (CRC) using Sirius red stain and immunoh
Curcumin enhances anti‑cancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells
Publikováno v:
Oncology Reports
Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has been reported to be a promising anti‑cancer drug in various human cancers. However, the effects of combination treatment of curcumin with gemcitabine or docetaxel on
Autor:
Kaijun Gao, Yangtao Jia, Haixiang Ding, Zhilong Yan, Xifeng Lao, Yu Yu, Chen Hang, Xiuchong Yu
Publikováno v:
Oncology Reports.
Gastrointestinal stromal tumors (GISTs) are the most commonly observed mesenchymal tumors of the digestive tract, and they originate from the interstitial cells of Cajal. GISTs can be divided into KIT/PDGFRA‑mutant GISTs and wild‑type GISTs based
Publikováno v:
Oncology Reports
Niclosamide is an FDA‑approved anthelmintic drug, and may elicit antineoplastic effects through direct STAT3 inhibition, which has been revealed in numerous human cancer cells. Chemotherapy is the standard treatment for advanced esophageal cancers,
Autor:
Jin Park, Seol Hwa Shin, Si Yeol Song, Jung Jin Hwang, Seung-Mo Hong, Eun Jin Ju, Seong-Yun Jeong, Shun'ich Kuroda, Eun Kyung Choi, Eun Jeong Ko, Joohee Jung, Kyoung Jin Lee, Jung Shin Lee, Seok Soon Park
Publikováno v:
Oncology Reports. 38:2259-2266
The incidence of hepatocellular carcinoma (HCC) has continued to increase worldwide, and advanced HCC is difficult to treat using the currently available therapeutics. Chemoradiotherapy with cisplatin (cis-diamminedichloroplatinum, CDDP) is expected
Autor:
Wade M. Mueller, Roger A. Sabbadini, Scott D. Rand, Christopher R. Chitambar, Shama P. Mirza, Kathleen M. Schmainda, Mona M. Al-Gizawiy, Jennifer Connelly, Ninh Doan, Ha S Nguyen
Publikováno v:
Oncology Reports
Glioblastoma multiforme (GBM) is the most common primary, intracranial malignancy of the central nervous system. The standard treatment protocol, which involves surgical resection, and concurrent radiation with adjuvant temozolomide (TMZ), still impa