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Autor:
Xue He, Xia Yuan, Zeting Yuan, Ting-ting Jia, Hui Yu, Ke Xu, Yuxia Yuan, Zou Yu, Yanyan Qiu, Peihao Yin, Shi Xiaojing, Cheng Liu
Publikováno v:
Oncology Reports. 37:1815-1825
Cinobufagin (CBF) is isolated from the skin and posterior auricular glands of the Asiatic toad (Bufo gargarizans). This study investigated the reversal effect of CBF on P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in colon cancer. The ef
Autor:
Kaname Yamamoto, Masamichi Sugimoto, Mitsue Kurasawa, Keigo Yorozu, Nobuyuki Ishikura, Mieko Yanagisawa
Publikováno v:
Oncology Reports
Although bevacizumab maintenance following bevacizumab in combination with chemotherapy has demonstrated significant prolongation of progression-free survival in clinical studies in patients with ovarian cancer, the majority of the cancer cases in th
Autor:
Chenyao Zhu, Zhang Yu, Hai-Yan Xie, Bo Wang, Lei Cao, Ning Xia, Ke-Ke Hao, Feng Liu, Guo-Jun Lu
Publikováno v:
Oncology Reports.
Lung cancer nanotherapeutics aim to overcome the limitations of conventional therapeutic methods. In the present study, a self‑assembled amphiphilic prodrug‑based nanocarrier delivery system was developed that exhibited high therapeutic efficienc
Publikováno v:
Oncology Reports. 36:315-323
Bone marrow (BM) suppression (also known as myelosuppression) is the most common and most severe side-effect of therarubicin (THP) and thereby limits the clinical application of this anticancer agent. Lentinan (LNT), a glucan extracted from dried shi
Autor:
Meng-Chi Yen, Wei-An Chang, Po-Lin Kuo, Ya-Wen Ho, Eing-Mei Tsai, Ming-Feng Hou, Cheng-Ying Wu, Jen-Yu Hung, Ya-Ling Hsu, Shu-Fang Jian
Publikováno v:
Oncology Reports. 34:2889-2900
Phthalates are used as plasticizers in the manufacture of flexible vinyl, which is used in food contact applications. Phthalates have been demonstrated to have an adverse impact on human health, particularly in terms of cancer development. In the pre
Publikováno v:
Oncology Reports.
In the present study, a lipid-polymer hybrid drug carrier system was developed to encapsulate psoralen (PSO), a multidrug resistance reversal agent and traditional Chinese medicine. Emphasis was focused the parameters that influence physicochemical c
Publikováno v:
Oncology Reports. 32:1647-1653
The molecular mechanisms underlying genistein-mediated reversal of chemoresistance remains unknown. In the present study, we investigated the molecular mechanisms by which genistein overcomes chemoresistance and its effect on doxorubicin-induced cyto
Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma
Autor:
Angela M. Liu, Qi Zhang, John M. Luk, Cuiju Tang, Zhi Xu, Xinying Huo, Yongling Gong, Jianmin Bian, Jinfei Chen
Publikováno v:
Oncology Reports. 29:840-846
Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies worldwide and is highly resistant to chemotherapy. Yes-associated protein (YAP) is the downstream effector of the Hippo signaling pathway, which is frequently overexpressed in
Publikováno v:
Oncology Reports
Limited distribution of anticancer drugs has been recognized as a significant hurdle to efficacy. We investigated a detailed penetration/distribution profile of paclitaxel-rhodamine (PTX-rd) and doxorubicin (DOX) in multicellular layer (MCL) cultures
Publikováno v:
Oncology Reports.
The major obstacle to tumor chemotherapy is drug resistance. In the present study, we investigated the characteristics of FaDu cells (a hypopharyngeal carcinoma cell line) with multidrug resistance (MDR) induced by Taxol. The resistant cell line, FaD