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Autor:
Caj Haglund, Tuomas Kaprio, Jaana Hagström, Ines Beilmann-Lehtonen, Karin Strigård, Richard Palmqvist, Ulf-Håkan Stenman, Ulf Gunnarsson, Camilla Böckelman
Publikováno v:
Oncology. 99:790-801
Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive protein (CRP) levels exhibit compromised prognoses. Toll-like receptors (TLRs), activating the innate and adapt
Autor:
Hye-Won Hwang, Mineui Hong, Yoon Yang Jung, Jung Hoon Lee, Jin Soo Lee, Sook-Hee Hong, Soon Auck Hong
Publikováno v:
Oncology
Background: Sex-determining region Y-box 2 (SOX2) is a transcriptional factor that drives embryonic stem cells to neuroendocrine cells in lung development and is highly expressed in small-cell lung cancer (SCLC). However, the prognostic role of SOX2
Autor:
Yu-Feng Tian, Pei-Ling Hsieh, Ching-Chieh Yang, Chia-Lin Chou, Yow-Ling Shiue, Sung-Wei Lee, Wan-Shan Li, Cheng-Yi Lin
Publikováno v:
Oncology. 98:549-557
Background/Aim: A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clini
Autor:
Seung Hyun Kim, Kyung Sik Kim, Hyae Min Jeon, Jae Seok Lee, Jin Suck Suh, Hong In Yoon, Hyo Song Kim, Kum Hee Yun, Kyu Hyun Park, Sunghoon Kim, Hyuk Hur, Soo Hee Kim, Min Kyung Jeon, Young Han Lee
Publikováno v:
Oncology. 98:817-826
Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas w
Autor:
Anna Maria Valentini, Rossella Donghia, Federica Di Pinto, Nicolo’ Schena, Raffaele Armentano, Graziana Arborea
Publikováno v:
Oncology. 98:566-574
To identify useful markers for prognostic and therapeutic purposes, The Cancer Genome Atlas (TCGA) provided a molecular classification of gastric cancers (GCs). Previous studies have used immunohistochemistry (IHC) and chromogenic in situ hybridizati
Autor:
Francesca Platini, Alba Bianco, Carlo Resteghini, Donata Galbiati, Massimo Milione, Cristiana Bergamini, Paolo Bossi, Lisa Licitra, Salvatore Alfieri, Stefano Cavalieri, Federica Perrone, Laura D. Locati
Publikováno v:
Oncology. 97:112-118
Background: Recurrent or metastatic (R/M) skin squamous cell carcinoma (sSCC) not amenable of surgery or irradiation may benefit from systemic therapies. Epidermal growth factor receptor (EGFR) inhibitors and, more recently, immune checkpoint blocker
Autor:
Nikolaos Nikiteas, Martin Bolli, Athanasios Tampakis, Gerasimos Tsourouflis, Alberto Posabella, Ekaterini Christina Tampaki, Markus von Flüe, Evangelos Felekouras, Gregory Kouraklis, Afroditi Nonni, Lana Fourie, Michael Kontos
Publikováno v:
Oncology. 99(7)
Background: Disease recurrence in colorectal cancer constitutes a major cause of significant cancer-associated morbidity and mortality. MAP17 is a small protein, and its overexpression in malignant tumors has been correlated with aggressive tumor phe
Autor:
Jaffer A. Ajani, Xuemei Wang, Allison Trail, Meina Zhao, Jeannelyn S. Estrella, Jane E. Rogers, Ahmed K. Abdelhakeem, Mariela Blum-Murphy
Publikováno v:
Oncology. 98(12)
Background: Prior studies have shown that patients whose tumor overexpresses Her2 at 3+ level by immunohistochemistry (IHC) fare better than those whose tumor overexpresses Her2 at 2+ level (with ERBB2 amplified). Therefore, it would be important to
Autor:
Guowu Wang, Wenhua Huang, Fan Sun, Lati Mu, Yong Zhong, Yong Tian, Jiangdong Wu, Yujie Xiao, Chaoqing Liu
Publikováno v:
Oncology. 98(3)
Purpose: RNA polymerase I subunit D (POLR1D) is involved in the synthesis of ribosomal RNA precursors and small RNAs, but its mechanism in the development and progression of colorectal cancer (CRC) remains ambiguous. Thus, this research aimed to inve
Autor:
Toshiyuki Suzuki, Hiroshi Miyakita, Lin Fung Chan, Hiroshi Kajiwara, Gota Saito, Takashi Ogimi, Kazutake Okada, Sotaro Sadahiro, Yutaro Kamei
Publikováno v:
Oncology. 97(5)
Background: Colorectal neuroendocrine carcinoma (NEC) is a rare disease, and mixed cases with colorectal adenocarcinoma also exist. The histogenesis of this disease remains unclear. We studied the numbers of neuroendocrine marker-positive cells in ad