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pro vyhledávání: ''
Autor:
Ines Beilmann-Lehtonen, Ulf-Håkan Stenman, Caj Haglund, Tuomas Kaprio, Kajsa Björkman, Camilla Böckelman
Publikováno v:
Oncology. 100:22-30
Objectives: Colorectal cancer is the third most common cancer worldwide, with an obvious need for more accurate prognostics. Previous studies identified C-reactive protein (CRP) as a prognostic serum biomarker for colorectal cancer, whereas the bioma
Autor:
Caj Haglund, Tuomas Kaprio, Jaana Hagström, Ines Beilmann-Lehtonen, Karin Strigård, Richard Palmqvist, Ulf-Håkan Stenman, Ulf Gunnarsson, Camilla Böckelman
Publikováno v:
Oncology. 99:790-801
Background: Colorectal cancer (CRC) is the third most commonly diagnosed malignancy globally. CRC patients with elevated plasma C-reactive protein (CRP) levels exhibit compromised prognoses. Toll-like receptors (TLRs), activating the innate and adapt
Autor:
Hitomi Sezaki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Fumitaka Suzuki, Tetsuya Hosaka, Yoshiyuki Suzuki, Masahiro Kobayashi, Yusuke Kawamura, Satoshi Saitoh, Shunichiro Fujiyama, Hiromitsu Kumada, Norio Akuta
Publikováno v:
Oncology. 99:114-123
Introduction: It remains unclear whether TERT promoter mutation (TERT C228T) in serum cell-free DNA (cfDNA) is useful for the diagnosis of hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD). Methods: In this retr
Autor:
Yu-Feng Tian, Pei-Ling Hsieh, Ching-Chieh Yang, Chia-Lin Chou, Yow-Ling Shiue, Sung-Wei Lee, Wan-Shan Li, Cheng-Yi Lin
Publikováno v:
Oncology. 98:549-557
Background/Aim: A great proportion of patients with rectal cancer initially present with locally advanced disease and can potentially benefit from neoadjuvant concurrent chemoradiotherapy (CCRT) for downstaging before surgery. However, risk and clini
Autor:
Masahiro Noda, Takaaki Arigami, Hiroshi Kurahara, Daisuke Matsushita, Satoshi Iino, Keishi Okubo, Yoshiaki Kita, Yoshikazu Uenosono, Yota Kawasaki, Shigehiro Yanagita, Sumiya Ishigami, Kosei Maemura, Shinichiro Mori, Ken Sasaki, Shoji Natsugoe
Publikováno v:
Oncology. 98:273-279
Objective: Chemotherapy is generally recommended as the first-line standard treatment in patients with liver metastasis from gastric cancer. However, the clinical impact of surgical treatment remains unclear in responders after chemotherapy. The pres
Autor:
Hiroshi Matsushita, Kazuhiro Nouso, Hiroyuki Terasawa, Takuya Adachi, Soichiro Ako, Yasuto Takeuchi, Mari Mandai, Akinobu Takaki, Hideki Onishi, Hidenori Shiraha, Tetsushige Mimura, Hideaki Kinugasa, Nozomu Wada, Hiroyuki Okada, Fusao Ikeda, Shinichi Fujioka
Publikováno v:
Oncology. 98:311-317
Background: Mutations in the human telomerase reverse transcriptase (hTERT) gene promoter have been reported in hepatocellular carcinoma (HCC); however, analyses of these mutations in liquid biopsies have been technically difficult because of the hig
Autor:
Eiji Oki, Yojiro Hashiguchi, Shigeki Yamaguchi, Masafumi Tanaka, Eiji Shinto, Naohiro Tomita, Tetsuya Kusumoto, Sachiyo Tada, Tomoko Matsushima, Kazuo Hase, Masaru Morita, Megumi Ishiguro, Mototsugu Shimokawa, Shinobu Ohnuma
Publikováno v:
Oncology. 98:534-541
Introduction: DNA microarrays, such as the consensus molecular subtype (CMS) classification using >600 genes, are used to predict cancer patient prognosis. We recently constructed a simple 55-gene classifier (55GC) system to risk stratify colon cance
Autor:
Shunsuke Miyamoto, Tetsutaro Hayashi, Jun Teishima, Go Kobayashi, Akio Matsubara, Hiroyuki Kitano, Yohei Sekino, Takashi Babasaki, Naohide Oue, Wataru Yasui, Keisuke Goto, Shogo Inoue, Naoya Sakamoto, Xiangrui Han, Kazuhiro Sentani
Publikováno v:
Oncology. 98:689-698
Background: βIII-Tubulin, encoded by the TUBB3 gene, is a microtubule protein. Several studies have shown that overexpression of TUBB3 is linked to poor prognosis and is involved in taxane resistance in some cancers. Objective: The aim of this study
Autor:
Hiroshi Shibata, Takashi Kumada, Kazuto Tajiri, Michitaka Imai, Masashi Hirooka, Atsushi Hiraoka, Norio Itokawa, Kunihiko Tsuji, Taeang Arai, Masatoshi Kudo, Kojiro Michitaka, Kazuya Kariyama, Shinya Fukunishi, Korenobu Hayama, Shinichiro Nakamura, Ei Itobayashi, Toru Ishikawa, Hironori Ochi, Yoichi Hiasa, Hideko Ohama, Akemi Tsutsui, Toshifumi Tada, Koichi Takaguchi, Masanori Atsukawa, Kazuhito Kawata, Noritomo Shimada, Hidenori Toyoda
Publikováno v:
Oncology. 98:295-302
Background/Aim: Few studies have examined the details of nutritional status in patients with unresectable hepatocellular carcinoma (u-HCC) undergoing systemic chemotherapy with lenvatinib. We evaluated the prognostic/predictive value of nutritional s
Autor:
Anna Maria Valentini, Rossella Donghia, Federica Di Pinto, Nicolo’ Schena, Raffaele Armentano, Graziana Arborea
Publikováno v:
Oncology. 98:566-574
To identify useful markers for prognostic and therapeutic purposes, The Cancer Genome Atlas (TCGA) provided a molecular classification of gastric cancers (GCs). Previous studies have used immunohistochemistry (IHC) and chromogenic in situ hybridizati