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pro vyhledávání: '"Sergio Lilla"'
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis
Autor:
Danny T. Huang, David Sumpton, Sergio Lilla, Lori Buetow, Syed Feroj Ahmed, William C. Clark, Gary J. Sibbet, Ann Hedley, Sara Zanivan, Mads Gabrielsen
Publikováno v:
Oncogene
Casitas B-lineage lymphoma (CBL) is a ubiquitin ligase (E3) that becomes activated upon Tyr371-phosphorylation and targets receptor protein tyrosine kinases for ubiquitin-mediated degradation. Deregulation of CBL and its E3 activity is observed in my
Autor:
Louise Mitchell, John R. P. Knight, Sara Zanivan, Sarah Slater, Chara Ntala, Janis Fleming, Joanne Edwards, Karen Blyth, Carl S. Goodyear, Ann Hedley, Kirsteen J. Campbell, Noor Akmar Nam, Mark Salji, Sheila Bryson, Hing Y. Leung, Craig N. Robson, Carolyn J. Loveridge, Rachana Patel, Imran Ahmad, Douglas Strathdee, Colin Nixon, Sergio Lilla, Matthew Neilson, Peter Repiscak
Publikováno v:
Loveridge, C J, Slater, S, Campbell, K J, Nam, N A, Knight, J, Ahmad, I, Hedley, A, Lilla, S, Repiscak, P, Patel, R, Salji, M, Fleming, J, Mitchell, L, Nixon, C, Strathdee, D, Neilson, M, Ntala, C, Bryson, S, Zanivan, S, Edwards, J, Robson, C N, Goodyear, C S, Blyth, K & Leung, H Y 2020, ' BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration ', Oncogene, vol. 39, no. 8, pp. 1797-1806 . https://doi.org/10.1038/s41388-019-1106-x
Oncogene
Oncogene
BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate
Autor:
Craig N. Robson, Imran Ahmad, Douglas Strathdee, Karen Blyth, John R. P. Knight, Colin Nixon, Sarah Slater, Matthew Neilson, Rachana Patel, Carl S. Goodyear, Peter Repiscak, Ann Hedley, Noor Akmar Nam, Carolyn J. Loveridge, Mark Salji, Sheila Bryson, Sergio Lilla, Sara Zanivan, Janis Fleming, Louise Mitchell, Joanne Edwards, Chara Ntala, Hing Y. Leung, Kirsteen J. Campbell
Publikováno v:
Oncogene. 39:2450-2450