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pro vyhledávání: '"Olena Barbash"'
Autor:
Anil K. Rustgi, Ming Zhou Guo, Olena Barbash, Fengmin Lu, James G. Herman, S Benzeno, Peter S. Klein, J A Diehl, Fangliang Zhang
Publikováno v:
Oncogene. 25:6291-6303
Although cyclin D1 is overexpressed in a significant number of human cancers, overexpression alone is insufficient to promote tumorigenesis. In vitro studies have revealed that inhibition of cyclin D1 nuclear export unmasks its neoplastic potential.
Publikováno v:
Oncogene
Protein ubiquitylation is a complex enzymatic process that results in the covalent attachment of ubiquitin, through Gly-76 of ubiquitin, to an varepsilonNH2 group of an internal lysine residue in a given substrate. Although E3 ligases frequently use