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pro vyhledávání: '"35"'
Autor:
Yi Wang, Xiaodong Zhang, Lihong Ye, Leilei Li, Weiying Zhang, Bowen Liu, Hui Shi, Runping Fang
Publikováno v:
Oncogene. 35:4048-4057
Reduction or loss of tumor-suppressor mammalian STE20-like kinase 1 (MST1) in Hippo pathway contributes to the tumorigenesis. However, the mechanism leading to reduction of MST1 in cancers remains poorly understood. In this study, we explored the hyp
Publikováno v:
Oncogene. 25:5527-5536
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depe
Publikováno v:
Oncogene. 25:1391-1399
We have previously shown that the breast cancer susceptibility gene, BRCA1, can transcriptionally activate the p27(Kip1) promoter. The BRCA1-responsive element was defined as a 35 bp region from position -545 to -511. We next determined that within t
Publikováno v:
Oncogene. 24:7830-7838
Protein kinase B (PKB) or Akt is one of several second messenger kinases that are activated by cell attachment and growth factor signaling, and that transmit signals to the cell nucleus to inhibit apoptosis and thereby increase cell survival during p