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Autor:
Takashi Nakamura, Mai Nampei, Takayo Murase, Hiroki Mizukami, Noriaki Katoh, Seigo Akari, Etsuko Satoh
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-5 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed stan
Autor:
Chun Liang, Changyu Li, Man Hei Cheung, Yu Dong, Meiai Lin, Yitao Chen, Wenjun Xu, Zhongxia Lu, Xin Wang
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-12 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Objectives The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism. Methods Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes w
Autor:
Yolanda Contreras-Vargas, Imelda González-Pérez, Karla Carvajal, Pedro Isauro Clavel-Pérez, Eduardo Rodríguez-Correa
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-15 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome
Autor:
John Hattersley, Ayman M. Arafat, Christian von Loeffelholz, Michael Roden, Gerd Schmitz, Natalia Rudovich, Ioannis Kyrou, Martin O. Weickert, Peter Nowotny, Andreas Pfeiffer, Silke Matysik
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-15 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
Abstract Bile acids (BA) are potent metabolic regulators influenced by diet. We studied effects of isoenergetic increases in the dietary protein and cereal-fiber contents on circulating BA and insulin resistance (IR) in overweight and obese adults. R
Publikováno v:
Nutrition & Diabetes
We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes. To test this, human aortic endothelial cells were treated with either ve
Publikováno v:
Nutrition & Diabetes
The mechanisms whereby prolonged plasma free fatty acids elevation, as found in obesity, causes hepatic insulin resistance are not fully clarified. We herein investigated whether inhibition of p38 mitogen-activated protein kinase (MAPK) prevented hep
Autor:
Dorit Samocha-Bonet, Helga Refsum, Fredrik Jernerén, Amany K. Elshorbagy, Leonie K. Heilbronn
Publikováno v:
Nutrition & Diabetes
Background: Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would