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Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Takashi Nakamura, Mai Nampei, Takayo Murase, Hiroki Mizukami, Noriaki Katoh, Seigo Akari, Etsuko Satoh
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-5 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed stan
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-11 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Backgrounds Mitochondria plays a critical role in the development and pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP) could lower blood glucose and prevent obesity in mice. However, the direct effect of NHP on hepatic st
Autor:
Yolanda Contreras-Vargas, Imelda González-Pérez, Karla Carvajal, Pedro Isauro Clavel-Pérez, Eduardo Rodríguez-Correa
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-15 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome
Autor:
Kálmán Bódis, Sabine Kahl, Marie-Christine Simon, Zhou Zhou, Henrike Sell, Birgit Knebel, Andrea Tura, Klaus Strassburger, Volker Burkart, Karsten Müssig, Daniel Markgraf, Hadi Al-Hasani, Julia Szendroedi, Michael Roden, for the GDS Study Group
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-9 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
Background In subcutaneous adipose tissue (SAT), higher stearoyl-CoA desaturase-1 (SCD1) expression has been related to improved insulin sensitivity in thiazolidinedione-treated type 2 diabetes mellitus patients. In animal models, deficiency of the f
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-8 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
OBJECTIVE Through dynamic means, etiological factors, including chronic inflammation and insulin resistance have the potential to perpetuate metabolic incidences such as type 2 diabetes and obesity. Abatement of such syndromes can be achieved by comp
Autor:
John Hattersley, Ayman M. Arafat, Christian von Loeffelholz, Michael Roden, Gerd Schmitz, Natalia Rudovich, Ioannis Kyrou, Martin O. Weickert, Peter Nowotny, Andreas Pfeiffer, Silke Matysik
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-15 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
Abstract Bile acids (BA) are potent metabolic regulators influenced by diet. We studied effects of isoenergetic increases in the dietary protein and cereal-fiber contents on circulating BA and insulin resistance (IR) in overweight and obese adults. R
Autor:
Ewa Anna Grzegorczyk, Barbara Choromańska, Ewa Harasim-Symbor, Piotr Mysliwiec, Bartlomiej Lukaszuk, Adrian Chabowski, Malgorzata Zendzian-Piotrowska, Dorota Harasiuk
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-10 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
Background/Objectives Fatty acid handling proteins are involved in the process of accumulation of lipids in different fat tissue depots. Thus, the aim of the study was to estimate the expression of both fatty acid transport and binding proteins in th
Publikováno v:
Nutrition & Diabetes
We hypothesized that metabolites of dietary flavonoids attenuate impairments in nitric oxide (NO) bioavailability evoked by glucotoxic conditions mimicking Type 1 or 2 diabetes. To test this, human aortic endothelial cells were treated with either ve
Autor:
Marlúcia Bastos Aires, Márcia Saldanha Kubrusly, A C V dos Santos, Luiz Augusto Carneiro D'Albuquerque, A C de Lima Luna, Daniel Andrada Maria
Publikováno v:
Nutrition & Diabetes
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic N