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Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Takashi Nakamura, Mai Nampei, Takayo Murase, Hiroki Mizukami, Noriaki Katoh, Seigo Akari, Etsuko Satoh
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-5 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed stan
Autor:
Chun Liang, Changyu Li, Man Hei Cheung, Yu Dong, Meiai Lin, Yitao Chen, Wenjun Xu, Zhongxia Lu, Xin Wang
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-12 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Objectives The study aimed to examine the anti-diabetic effects of Gynura divaricata (GD) and the underlying mechanism. Methods Information about the chemical compositions of GD was obtained from extensive literature reports. Potential target genes w
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-11 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Backgrounds Mitochondria plays a critical role in the development and pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP) could lower blood glucose and prevent obesity in mice. However, the direct effect of NHP on hepatic st
Autor:
Yolanda Contreras-Vargas, Imelda González-Pérez, Karla Carvajal, Pedro Isauro Clavel-Pérez, Eduardo Rodríguez-Correa
Publikováno v:
Nutrition & Diabetes, Vol 10, Iss 1, Pp 1-15 (2020)
Nutrition & Diabetes
Nutrition & Diabetes
Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-8 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
OBJECTIVE Through dynamic means, etiological factors, including chronic inflammation and insulin resistance have the potential to perpetuate metabolic incidences such as type 2 diabetes and obesity. Abatement of such syndromes can be achieved by comp
Publikováno v:
Nutrition & Diabetes, Vol 8, Iss 1, Pp 1-10 (2018)
Nutrition & Diabetes
Nutrition & Diabetes
Glycerol-3-phosphate acyltransferase (GPAT) is the rate-limiting enzyme in the de novo pathway of glycerolipid synthesis. It catalyzes the conversion of glycerol-3-phosphate and long-chain acyl-CoA to lysophosphatidic acid. In mammals, four isoforms
Autor:
Marlúcia Bastos Aires, Márcia Saldanha Kubrusly, A C V dos Santos, Luiz Augusto Carneiro D'Albuquerque, A C de Lima Luna, Daniel Andrada Maria
Publikováno v:
Nutrition & Diabetes
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic N
Autor:
Mette Olaf Nielsen, Kirsten Raun, Marina Kjaergaard, Cecilia Nilsson, Jonas Kildegaard, Anna Secher, Kevin L. Grove, Tine Skovgaard
Publikováno v:
Nutrition & Diabetes
Gerstenberg, M K, Nilsson, C, Secher, A, Kildegaard, J, Skovgaard, T, Nielsen, M O, Grove, K & Raun, K 2017, ' Differential hypothalamic leptin sensitivity in obese rat offspring exposed to maternal and postnatal intake of chocolate and soft drink ', Nutrition and Diabetes, vol. 7, no. 1, e242 . https://doi.org/10.1038/nutd.2016.53
Gerstenberg, M K, Nilsson, C, Secher, A, Kildegaard, J, Skovgaard, T, Nielsen, M O, Grove, K & Raun, K 2017, ' Differential hypothalamic leptin sensitivity in obese rat offspring exposed to maternal and postnatal intake of chocolate and soft drink ', Nutrition and Diabetes, vol. 7, no. 1, e242 . https://doi.org/10.1038/nutd.2016.53
Background/objective: Intake of high-energy foods and maternal nutrient overload increases the risk of metabolic diseases in the progeny such as obesity and diabetes. We hypothesized that maternal and postnatal intake of chocolate and soft drink will
Publikováno v:
Nutrition & Diabetes
The mechanisms whereby prolonged plasma free fatty acids elevation, as found in obesity, causes hepatic insulin resistance are not fully clarified. We herein investigated whether inhibition of p38 mitogen-activated protein kinase (MAPK) prevented hep