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pro vyhledávání: '"Mark A Wainberg"'
Publikováno v:
Nucleosidesnucleotides. 18(4-5)
Resistant variants were selected in vitro against two novel nucleoside analogues, (+) dOTC and (-) dOTFC using the HIV-1 molecular clone HXB2D. The variants obtained displayed 6.5-fold and 10-fold resistance to these compounds, respectively. Cloning
Autor:
P. Nguyen-Ba, J.-M. De Muys, Zhengxian Gu, Mark A. Wainberg, Robert F. Rando, Lucille L'Heureux
Publikováno v:
Nucleosidesnucleotides. 18(4-5)
DXG and its prodrug DAPD have been demonstrated to be effective inhibitors of HIV-1 in various cells. The EC50s for DXG were 0.032 microM in CBMCs and 0.05 microM in MT-4 cells, which were generally equipotent as 3TC. 3TC-resistant, but not AZT-resis
Autor:
Horacio Salomón, Marisa I. Motura, Guillermo N. Moroni, Mark A. Wainberg, Margarita C. Briñón
Publikováno v:
Nucleosidesnucleotides. 18(3)
A novel cyclic bromine zidovudine analog, (-)-trans-(5S,6S)-5-bromo-6,5′-epoxy-5,6-dihydro-3′-azido-3′-deoxythymidine (2), and its diastereoisomer (+)-trans-(5R,6R)-(3) were synthesized and characterized by spectroscopic methods, obtaining 3 in