Zobrazeno 1 - 10
of 651
pro vyhledávání: ''
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, In press, ⟨10.1093/nar/gkac346⟩
Nucleic Acids Research, In press, ⟨10.1093/nar/gkac346⟩
Promoters and enhancers are sites of transcription initiation (TSSs) and carry active histone modifications, including H3K4me1, H3K4me3, and H3K27ac. Yet, the principles governing the boundaries of such regulatory elements are still poorly characteri
Autor:
Tamara Phan, Pallab Maity, Christina Ludwig, Lisa Streit, Miltiadis Tsesmelis, Sebastian Iben, Karin Scharffetter-Kochanek, Jens Michaelis
Publikováno v:
Nucleic Acids Research
Ribosome biogenesis is a highly energy-demanding process in eukaryotes which requires the concerted action of all three RNA polymerases. In RNA polymerase II transcription, the general transcription factor TFIIH is recruited by TFIIE to the initiatio
Publikováno v:
Nucleic Acids Research
Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it is unclear whether and how the two other RNA polymerases dimerize. Here we present th
Publikováno v:
Nucleic Acids Research
R-loops, which consist of a DNA/RNA hybrid and a displaced single-stranded DNA (ssDNA), are increasingly recognized as critical regulators of chromatin biology. R-loops are particularly enriched at gene promoters, where they play important roles in r
Autor:
Zhongming Zhao, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Xu Feng, Dan Su, Guangsheng Pei, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we perfo
Autor:
Hyeonju Woo, Sumin Lee, Bo Bae Lee, Jae Seok Roe, TaeSoo Kim, SeoJung Youn, Min Kyung Lee, Soo Young Lee
Publikováno v:
Nucleic Acids Research
During RNA polymerase II (RNA Pol II) transcription, the chromatin structure undergoes dynamic changes, including opening and closing of the nucleosome to enhance transcription elongation and fidelity. These changes are mediated by transcription elon
Publikováno v:
Nucleic Acids Research
Transcription induced CAG repeat instability is associated with fatal neurological disorders. Genetic approaches found transcription-coupled nucleotide excision repair (TC-NER) factor CSB protein and TFIIS play critical roles in modulating the repeat
Autor:
Cornelia Broenner, Pablo Monteagudo, Stefan Canzar, Parastou Kohvaei, Haris Amedi, Mario Halic
Publikováno v:
Nucleic acids research. 50(10)
Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and
Autor:
Josh Lawrimore, Elaine Yeh, Muznah Khan, Daniel Kolbin, Kerry Bloom, Colleen J. Lawrimore, Solenn C de Larminat, John Stanton
Publikováno v:
Nucleic Acids Research
The nucleolus is the site of ribosome biosynthesis encompassing the ribosomal DNA (rDNA) locus in a phase separated state within the nucleus. In budding yeast, we find the rDNA locus and Cdc14, a protein phosphatase that co-localizes with the rDNA, b
Autor:
Hong-Yeoul Ryu, Mark Hochstrasser
Publikováno v:
Nucleic Acids Research
Chromatin structure and gene expression are dynamically controlled by post-translational modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation and small ubiquitin-like modifier (SUMO) conjugation. It was initial