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Publikováno v:
Nucleic Acids Research
Transcriptional fidelity, which prevents the misincorporation of incorrect nucleoside monophosphates in RNA, is essential for life. Results from molecular dynamics (MD) simulations of eukaryotic RNA polymerase (RNAP) II and bacterial RNAP with experi
Autor:
Marie-Hélène Guilleux, Christine Kervarrec, Ronald W. Davis, Karl Waern, Joe Horecka, Angela Chu, Fatima Smagulova, Randy Strich, Michael Primig, Yuchen Liu, Michael Snyder, Aurélie Lardenois, Michael J. Law, Lars M. Steinmetz, Igor Stuparević, Emmanuelle Becker
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2015, 43 (1), pp.115-28. ⟨10.1093/nar/gku1185⟩
Nucleic Acids Research, Oxford University Press, 2015, 43 (1), pp.115-28. ⟨10.1093/nar/gku1185⟩
Nucleic Acids Research, 2015, 43 (1), pp.115-28. ⟨10.1093/nar/gku1185⟩
Nucleic Acids Research, Oxford University Press, 2015, 43 (1), pp.115-28. ⟨10.1093/nar/gku1185⟩
International audience; It was recently reported that the sizes of many mRNAs change when budding yeast cells exit mitosis and enter the meiotic differentiation pathway. These differences were attributed to length variations of their untranslated reg
Publikováno v:
Nucleic Acids Research
Efficient transcription of the HIV-1 genome is regulated by Tat, which recruits P-TEFb from the 7SK small nuclear ribonucleoprotein (snRNP) and other nucleoplasmic complexes to phosphorylate RNA polymerase II and other factors associated with the tra
Publikováno v:
Nucleic Acids Research
Recent studies have disclosed the function of enhancer RNAs (eRNAs), which are long non-coding RNAs transcribed from gene enhancer regions, in transcriptional regulation. However, it remains unclear whether eRNAs are involved in the regulation of hum
Publikováno v:
Nucleic Acids Research
Transcription-coupled DNA repair (TCR) is a subpathway of nucleotide excision repair (NER) dedicated to rapid removal of DNA lesions in the transcribed strand of actively transcribed genes. The precise nature of the TCR signal and how the repair mach
Autor:
Christopher K. Glass, Christopher Benner, Jarkko Laitalainen, Casey E. Romanoski, Emilia Kansanen, Sven Heinz, Seppo Ylä-Herttuala, Minna U. Kaikkonen, Henri Niskanen, Annukka M. Kivelä
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 42, iss 20
Nucleic acids research, vol 42, iss 20
Vascular endothelial growth factor A (VEGF-A) is a master regulator of angiogenesis, vascular development and function. In this study we investigated the transcriptional regulation of VEGF-A-responsive genes in primary human aortic endothelial cells
Autor:
Bhawana Uprety, Shweta Lahudkar, Shivani Malik, Sukesh R. Bhaumik, Rwik Sen, Sarah Frankland-Searby
Publikováno v:
Nucleic Acids Research
Rrd1p (resistance to rapamycin deletion 1) has been previously implicated in controlling transcription of rapamycin-regulated genes in response to rapamycin treatment. Intriguingly, we show here that Rrd1p associates with the coding sequence of a gal
Autor:
Kyle A. Nilson, Benjamin M Spector, David H. Price, Jeffery L. Meier, Christopher B. Ball, Christine K. Lawson, Nicholas J. Mullen
Publikováno v:
Nucleic Acids Research
Oxidative stress has pervasive effects on cells but how they respond transcriptionally upon the initial insult is incompletely understood. We developed a nuclear walk-on assay that semi-globally quantifies nascent transcripts in promoter-proximal pau
Publikováno v:
Nucleic Acids Research
DNA N6-methyladenine (6mA) is newly rediscovered as a potential epigenetic mark across a more diverse range of eukaryotes than previously realized. As a unicellular model organism, Tetrahymena thermophila is among the first eukaryotes reported to con
Publikováno v:
Nucleic Acids Research
Rpc82 is a TFIIE-related subunit of the eukaryotic RNA polymerase III (pol III) complex. Rpc82 contains four winged-helix (WH) domains and a C-terminal coiled-coil domain. Structural resolution of the pol III complex indicated that Rpc82 anchors on t