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Autor:
Anna Marie Pyle, Thayne H. Dickey
Publikováno v:
Nucleic Acids Research
Several members of the SMAD family of transcription factors have been reported to bind RNA in addition to their canonical double-stranded DNA (dsDNA) ligand. RNA binding by SMAD has the potential to affect numerous cellular functions that involve RNA
Publikováno v:
Nucleic Acids Research
SIRT7 is an NAD+-dependent protein deacetylase that regulates cell growth and proliferation. Previous studies have shown that SIRT7 is required for RNA polymerase I (Pol I) transcription and pre-rRNA processing. Here, we took a proteomic approach to
Publikováno v:
Nucleic Acids Research
Pervasive transcription is widespread and needs to be controlled in order to avoid interference with gene expression. In Saccharomyces cerevisiae, the highly conserved helicase Sen1 plays a key role in restricting pervasive transcription by eliciting
Autor:
Thomas A. Steitz, Bin Liu
Publikováno v:
Nucleic Acids Research
NusG is an essential transcription factor that plays multiple key regulatory roles in transcription elongation, termination and coupling translation and transcription. The core role of NusG is to enhance transcription elongation and RNA polymerase pr
Autor:
Beate Schwer, Christina M. Homer, Jahan Yar Parsa, Robert J. Nichols, Hiten D. Madhani, Maki Inada, Jeffrey A. Pleiss, Ruby A. Benn, Reyal S. Hoxie, Stewart Shuman
Publikováno v:
Nucleic Acids Research
Eukaryotic gene expression requires that RNA Polymerase II (RNAP II) gain access to DNA in the context of chromatin. The C-terminal domain (CTD) of RNAP II recruits chromatin modifying enzymes to promoters, allowing for transcription initiation or re
Publikováno v:
Nucleic Acids Research
Release of RNA polymerase II (Pol II) from promoter-proximal pausing has emerged as a critical step regulating gene expression in multicellular organisms. The transition of Pol II into productive elongation requires the kinase activity of positive tr
Publikováno v:
Nucleic Acids Research
Trypanosomes are protistan parasites that diverged early in evolution from most eukaryotes. Their streamlined genomes are packed with arrays of tandemly linked genes that are transcribed polycistronically by RNA polymerase (pol) II. Individual mRNAs
Publikováno v:
Nucleic Acids Research
RNA polymerase II (RNAPII) passes through the nucleosome in a coordinated manner, generating several intermediate nucleosomal states as it breaks and then reforms histone–DNA contacts ahead of and behind it, respectively. Several studies have defin
Autor:
Lijian Yu, Michael R. Volkert
Publikováno v:
Nucleic Acids Research
Alternative polyadenylation (APA) is conserved in all eukaryotic cells. Selective use of polyadenylation sites appears to be a highly regulated process and contributes to human pathogenesis. In this article we report that the yeast RPB2 gene is alter
Autor:
Jeffrey A. Rosenfeld, Anish Das, Mahrukh Banday, Yun-Juan Chang, Michael A. Fisher, Vivian Bellofatto
Publikováno v:
Nucleic Acids Research
A unique feature of RNA polymerase II (RNA pol II) is its long C-terminal extension, called the carboxy-terminal domain (CTD). The well-studied eukaryotes possess a tandemly repeated 7-amino-acid sequence, called the canonical CTD, which orchestrates