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Publikováno v:
Nucleic Acids Research
The ChIP-exo assay precisely delineates protein-DNA crosslinking patterns by combining chromatin immunoprecipitation with 5′ to 3′ exonuclease digestion. Within a regulatory complex, the physical distance of a regulatory protein to DNA affects cr
Autor:
Xinyue Wei, Dapeng Liang, Siqi Zhao, Haidong Zhao, Baohui Zhu, Qi Wang, Shuai Hou, Dajun Qu, Liye Zhang, Misbah Khan, Haixin Lei, Wei Guo, Jiaojiao Hao, Yue Li, Wei Tang, Weijie Wang, Qian Zhang, Sikandar Azam
Publikováno v:
Nucleic Acids Research
XAB2 is a multi-functional protein participating processes including transcription, splicing, DNA repair and mRNA export. Here, we report POLR2A, the largest catalytic subunit of RNA polymerase II, as a major target gene down-regulated after XAB2 dep
Autor:
Sunyoung Chae, Sunwoo Min, Y. C. Kim, Jae-Hoon Ji, Chang-Woo Lee, Hyeseong Cho, Geun-Hyoung Ha, Yeon Ji Park
Publikováno v:
Nucleic Acids Research
Histone H2AX undergoes a phosphorylation switch from pTyr142 (H2AX-pY142) to pSer139 (γH2AX) in the DNA damage response (DDR); however, the functional role of H2AX-pY142 remains elusive. Here, we report a new layer of regulation involving transcript
Publikováno v:
Nucleic Acids Research
The general transcription factor P-TEFb, a master regulator of RNA polymerase (Pol) II elongation, phosphorylates the C-terminal domain (CTD) of Pol II and negative elongation factors to release Pol II from promoter-proximal pausing. We show here tha
Autor:
Yuhui Dou, Hua Jiang, Kelly R. Molloy, Wiebke Manuela Schulze, Hervé Le Hir, Torben Heick Jensen, Manfred Schmid, Claudia Iasillo, Isabelle Barbosa, Stephen Cusack, John LaCava
Publikováno v:
Nucleic Acids Research
Dou, Y, Barbosa, I, Jiang, H, Iasillo, C, Molloy, K R, Schulze, W M, Cusack, S, Schmid, M, Le Hir, H, LaCava, J & Jensen, T H 2020, ' NCBP3 positively impacts mRNA biogenesis ', Nucleic Acids Research, vol. 48, no. 18, pp. 10413-10427 . https://doi.org/10.1093/nar/gkaa744
Nucleic Acids Research, 48(18), 10413-10427. Oxford University Press
Nucleic Acids Research, Oxford University Press, 2020, 48 (18), pp.10413-10427. ⟨10.1093/nar/gkaa744⟩
Dou, Y, Barbosa, I, Jiang, H, Iasillo, C, Molloy, K R, Schulze, W M, Cusack, S, Schmid, M, Le Hir, H, LaCava, J & Jensen, T H 2020, ' NCBP3 positively impacts mRNA biogenesis ', Nucleic Acids Research, vol. 48, no. 18, pp. 10413-10427 . https://doi.org/10.1093/nar/gkaa744
Nucleic Acids Research, 48(18), 10413-10427. Oxford University Press
Nucleic Acids Research, Oxford University Press, 2020, 48 (18), pp.10413-10427. ⟨10.1093/nar/gkaa744⟩
The nuclear Cap-Binding Complex (CBC), consisting of Nuclear Cap-Binding Protein 1 (NCBP1) and 2 (NCBP2), associates with the nascent 5′cap of RNA polymerase II transcripts and impacts RNA fate decisions. Recently, the C17orf85 protein, also called
Autor:
Ronald C. Conaway, Preeti Dabas, Charles A.S. Banks, Ying Zhang, Dana M. Gibbon, Christopher Seidel, Nimisha Sharma, Joan W. Conaway, Sneha Gopalan, Laurence Florens, Michael P. Washburn
Publikováno v:
Nucleic Acids Research
ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause. In metazoa, ELL regulates Pol II transcription elongation as part o
Publikováno v:
Nucleic Acids Research
Alternative splicing (AS) is a regulatory mechanism of gene expression that greatly expands the coding capacities of genomes by allowing the generation of multiple mRNAs from a single gene. In Drosophila, the mod(mdg4) locus is an extreme example of
Autor:
Xiu-E Xu, Xiao-Dan Zhang, Yong-Mei Song, En-Min Li, Ying-Hua Xie, Guo-Wei Huang, Yang-Min Xie, Li-Yan Xu, Jin-Cheng Guo, Lian-Di Liao, Jian-Zhong He
Publikováno v:
Nucleic Acids Research
EZR, a member of the ezrin-radixin-moesin (ERM) family, is involved in multiple aspects of cell migration and cancer. SMYD3, a histone H3–lysine 4 (H3–K4)-specific methyltransferase, regulates EZR gene transcription, but the molecular mechanisms
Autor:
Animesh Chowdhury, Moshe Szyf, Matthew Suderman, Swati Srivastava, Moshit Lindzen, Cindy Körner, Moshe Oren, Stefan Wiemann, Kirti Shukla, Noa Furth, Yehoshua Enuka, Yoav Zaltsman, Mattia Lauriola, Renaud Massart, Yosef Yarden, Morris E. Feldman, Aldema Sas-Chen, Chiara A. Mazza, David Cheishvili
Publikováno v:
Nucleic Acids Research
Crosstalk between growth factors (GFs) and steroid hormones recurs in embryogenesis and is co-opted in pathology, but underlying mechanisms remain elusive. Our data from mammary cells imply that the crosstalk between the epidermal GF and glucocortico
Autor:
Carlos Fernández-Tornero, Noelia González-Polo, Jaime Alegrio Louro, Miguel Garavís, Paula Allepuz-Fuster, Olga Calvo
Publikováno v:
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
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Biogenesis ofmessenger RNA is critically influenced by the phosphorylation state of the carboxy-terminal domain (CTD) in the largest RNA polymerase II(RNAPII) subunit. Several kinases and phosphatases are required to maintain proper CTD phosphorylati