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Autor:
Zhongming Zhao, Junjie Chen, Chao Wang, Zhen Chen, Mengfan Tang, Xu Feng, Dan Su, Guangsheng Pei, Mrinal Srivastava
Publikováno v:
Nucleic Acids Research
Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we perfo
Autor:
Binkai Chi, Yong Yu, Jaya Gangopadhyay, Alexander D Iocolano, Jordan A Coady, Steven P. Gygi, Robin Reed, Jeremy D. O’Connell
Publikováno v:
Nucleic Acids Research
Understanding the molecular pathways disrupted in motor neuron diseases is urgently needed. Here, we employed CRISPR knockout (KO) to investigate the functions of four ALS-causative RNA/DNA binding proteins (FUS, EWSR1, TAF15 and MATR3) within the RN
Publikováno v:
Nucleic Acids Research
Briggs, E, Hamilton, G, Crouch, K, Lapsley, C & McCulloch, R 2018, ' Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome ', Nucleic Acids Research, vol. 46, no. 22, pp. 11789–11805 . https://doi.org/10.1093/nar/gky928
Briggs, E, Hamilton, G, Crouch, K, Lapsley, C & McCulloch, R 2018, ' Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome ', Nucleic Acids Research, vol. 46, no. 22, pp. 11789–11805 . https://doi.org/10.1093/nar/gky928
R-loops are stable RNA-DNA hybrids that have been implicated in transcription initiation and termination, as well as in telomere homeostasis, chromatin formation, and genome replication and instability. RNA Polymerase (Pol) II transcription in the pr
Autor:
Eun Byeol Park, Hye Ri Kang, Woo Chang Chung, Yee Ching Ng, Hye Jeong Cho, Moon Jung Song, Suk-Jo Kang
Publikováno v:
Nucleic Acids Research
DExD/H-box helicase 9 (DHX9), or RNA helicase A (RHA), is an abundant multifunctional nuclear protein. Although it was previously reported to act as a cytosolic DNA sensor in plasmacytoid dendritic cells (pDCs), the role and molecular mechanisms of a
Autor:
Ronald C. Conaway, Preeti Dabas, Charles A.S. Banks, Ying Zhang, Dana M. Gibbon, Christopher Seidel, Nimisha Sharma, Joan W. Conaway, Sneha Gopalan, Laurence Florens, Michael P. Washburn
Publikováno v:
Nucleic Acids Research
ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause. In metazoa, ELL regulates Pol II transcription elongation as part o
Publikováno v:
Nucleic Acids Research
Alternative splicing (AS) is a regulatory mechanism of gene expression that greatly expands the coding capacities of genomes by allowing the generation of multiple mRNAs from a single gene. In Drosophila, the mod(mdg4) locus is an extreme example of
Autor:
J. Pablo Radicella, Hannes Lans, Roel C. Janssens, Franziska Wienholz, Jurgen A. Marteijn, Arjan F. Theil, Anna Campalans, Hervé Menoni, Wim Vermeulen
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2018, 46 (15), pp.7747-7756. ⟨10.1093/nar/gky579⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (15), pp.7747-7756. ⟨10.1093/nar/gky579⟩
Nucleic Acids Research, 46(15), 7747-7756. Oxford University Press
Nucleic Acids Research, 2018, 46 (15), pp.7747-7756. ⟨10.1093/nar/gky579⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (15), pp.7747-7756. ⟨10.1093/nar/gky579⟩
Nucleic Acids Research, 46(15), 7747-7756. Oxford University Press
International audience; Transcription-coupled nucleotide excision repair factor Cockayne syndrome protein B (CSB) was suggested to function in the repair of oxidative DNA damage. However thus far, no clear role for CSB in base excision repair (BER),
Autor:
Liangqun Huang, Alison K Thurston, Laurie A. Stargell, Xu Chen, Sha Li, Jeffrey C. Hansen, Catherine A. Radebaugh, Anna A. Kalashnikova, Adam R. Almeida, Karolin Luger, Ling Zhang
Publikováno v:
Nucleic Acids Research
The process of transcriptional elongation by RNA polymerase II (RNAPII) in a chromatin context involves a large number of crucial factors. Spn1 is a highly conserved protein encoded by an essential gene and is known to interact with RNAPII and the hi
Autor:
Joseph Azofeifa, Phillip A. Richmond, Qinghong Zhang, Xuedong Liu, Cathryn M Toomey, Graycen Wheeler, Robin D. Dowell, Eric Bunker, Samuel S Karman, Aaron T. Garnett, Gilson J Sanchez, Quanbin Xu
Publikováno v:
Nucleic Acids Research
Histone deacetylase inhibitors (HDACIs) are known to alter gene expression by both up- and down-regulation of protein-coding genes in normal and cancer cells. However, the exact regulatory mechanisms of action remain uncharacterized. Here we investig
Autor:
Xiu-E Xu, Xiao-Dan Zhang, Yong-Mei Song, En-Min Li, Ying-Hua Xie, Guo-Wei Huang, Yang-Min Xie, Li-Yan Xu, Jin-Cheng Guo, Lian-Di Liao, Jian-Zhong He
Publikováno v:
Nucleic Acids Research
EZR, a member of the ezrin-radixin-moesin (ERM) family, is involved in multiple aspects of cell migration and cancer. SMYD3, a histone H3–lysine 4 (H3–K4)-specific methyltransferase, regulates EZR gene transcription, but the molecular mechanisms