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Publikováno v:
Nucleic Acids Research
Cleavage and polyadenylation (C/P) of mRNA is an important cellular process that promotes increased diversity of mRNA isoforms and could change their stability in different cell types. The cleavage stimulation factor (CstF) complex, part of the C/P m
Autor:
Laura I. Marquez Loza, Brajesh K. Singh, Linda S. Powers, Ian M. Thornell, Ashley L. Cooney, Camilla E Hippee, Chris Wohlford-Lenane, David A. Stoltz, Lynda S. Ostedgaard, Paul B. McCray, Patrick L. Sinn, David K. Meyerholz
Publikováno v:
Nucleic Acids Research
Cystic fibrosis (CF) is a common genetic disease caused by mutations in the gene coding for cystic fibrosis transmembrane conductance regulator (CFTR). Although CF affects multiple organ systems, chronic bacterial infections and inflammation in the l
Autor:
Anita H. Corbett, Grace K. Pavlath, Ayan Banerjee, Sergio Di Marco, Brittany L. Phillips, Imed-Eddine Gallouzi, Brenda Janice Sanchez
Publikováno v:
Nucleic Acids Research
RNA processing is critical for proper spatial and temporal control of gene expression. The ubiquitous nuclear polyadenosine RNA binding protein, PABPN1, post-transcriptionally regulates multiple steps of gene expression. Mutations in the PABPN1 gene
Autor:
Brian G. Pierce, Ragul Gowthaman
Publikováno v:
Nucleic Acids Research
T cell receptors (TCRs), along with antibodies, are responsible for specific antigen recognition in the adaptive immune response, and millions of unique TCRs are estimated to be present in each individual. Understanding the structural basis of TCR ta
Autor:
Shih-Hsun Chen, Nils G. Walter, Muzaffer Ahmad Kassab, Guang Yang, Chao Liu, J. Damon Hoff, Xiaochun Yu
Publikováno v:
Nucleic Acids Research
DNA double-strand breaks (DSBs) are fatal DNA lesions and activate a rapid DNA damage response. However, the earliest stage of DSB sensing remains elusive. Here, we report that PARP1 and the Ku70/80 complex localize to DNA lesions considerably earlie
Publikováno v:
Nucleic Acids Research
Long interspersed nuclear element 1 is an autonomous non-long terminal repeat retrotransposon that comprises ∼17% of the human genome. Its spontaneous retrotransposition and the accumulation of heritable L1 insertions can potentially result in geno
Autor:
Atul Kakrana, S. Deepthi Ramachandruni, Deepti Anand, Djordje Djordjevic, Joshua W. K. Ho, Andrian Yang, Abhyudai Singh, Hongzhan Huang, Salil A. Lachke
Publikováno v:
Nucleic Acids Research
Although successful in identifying new cataract-linked genes, the previous version of the database iSyTE (integrated Systems Tool for Eye gene discovery) was based on expression information on just three mouse lens stages and was functionally limited
Autor:
Ganesh N. Pandian, Takuya Hidaka, Junichi Taniguchi, Kaori Hashiya, Hiroshi Sugiyama, Toshikazu Bando, Kyeong Kyu Kim
Publikováno v:
Nucleic Acids Research
Targeted differentiation of human induced pluripotent stem cells (hiPSCs) using only chemicals would have value-added clinical potential in the regeneration of complex cell types including cardiomyocytes. Despite the availability of several chemical
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2017, 45 (14), pp.8190-8198. ⟨10.1093/nar/gkx556⟩
Nucleic Acids Research, Oxford University Press, 2017, 45 (14), pp.8190-8198. ⟨10.1093/nar/gkx556⟩
Nucleic Acids Research, 2017, 45 (14), pp.8190-8198. ⟨10.1093/nar/gkx556⟩
Nucleic Acids Research, Oxford University Press, 2017, 45 (14), pp.8190-8198. ⟨10.1093/nar/gkx556⟩
International audience; Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely
Autor:
Jason W. Rausch, Stuart F. J. Le Grice, Jennifer T. Miller, Rodman Smith, Denise Whitby, Joanna Sztuba-Solinska
Publikováno v:
Nucleic Acids Research
Kaposi's sarcoma-associated herpes virus (KSHV) polyadenylated nuclear (PAN) RNA facilitates lytic infection, modulating the cellular immune response by interacting with viral and cellular proteins and DNA. Although a number nucleoprotein interaction