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pro vyhledávání: '"Shawn L. Hervey-Jumper"'
Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event
Autor:
Marcia Leonard, Stefanie Stallard, Pedro R. Lowenstein, Carl Koschmann, Sriram Venneti, Xuhong Cao, Valerie P. Opipari, Katayoon Kasaian, Daniel Zamler, Hugh J. L. Garton, Rajen Mody, Karin M. Muraszko, Luigi Franchi, Arul M. Chinnaiyan, Shawn L. Hervey-Jumper, Patricia L. Robertson, Maria G. Castro, Zishaan Farooqui
Publikováno v:
npj Precision Oncology, Vol 1, Iss 1, Pp 1-4 (2017)
NPJ Precision Oncology
NPJ Precision Oncology
Improved molecular understanding is needed for rational treatment of diffuse intrinsic pontine gliomas (DIPG). Here, using multi-focal paired tumor and germline exome DNA and RNA sequencing, we uncovered phosphatase and tensin homolog (PTEN) loss as