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Autor:
Fernando D. Martinez
Publikováno v:
New England Journal of Medicine. 375:871-878
The conventional thinking about COPD is that exposures in adult life, such as smoking, lead to a low FEV1:FVC ratio, the physiological hallmark of COPD. In this review, the effect of early-life exposures on the lung that could lead to expiratory airf
Autor:
Birgit Funke, Bradley A. Maron, Arjun K. Manrai, Isaac S. Kohane, David M. Margulies, Joseph Loscalzo, Heidi L. Rehm, Morten S. Olesen, Peter Szolovits
Publikováno v:
New England Journal of Medicine. 375:655-665
BackgroundFor more than a decade, risk stratification for hypertrophic cardiomyopathy has been enhanced by targeted genetic testing. Using sequencing results, clinicians routinely assess the risk of hypertrophic cardiomyopathy in a patient’s relati
Autor:
Yuhua Shi, Yongle Xu, Yunxia Cao, Yun Sun, Li Feng Tian, Bo Zhang, Junhao Yan, Zi-Jiang Chen, Ning Weng, Richard S. Legro, Cuifang Hao, Jing Li, Yingying Qin, Xiaoyan Liang, Jiayin Liu, Dongzi Yang, Heping Zhang, Jing Yang, Han Zhao, Juanzi Shi, Daimin Wei, Feng Zhou
Publikováno v:
New England Journal of Medicine. 375:523-533
The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyper
Autor:
Gayle Hd, Jane E Henney
Publikováno v:
New England Journal of Medicine. 381:597-598
Time to Reevaluate U.S. Mifepristone Restrictions After nearly two decades of use, research, and a comprehensive review, all of which clearly demonstrate that mifepristone is extremely safe and eff...
Autor:
Lisa H. Harris
Publikováno v:
New England Journal of Medicine. 378:1369-1371
Divisions, New and Old In creating a Conscience and Religious Freedom Division, leaders of the U.S. Department of Health and Human Services have framed “conscience” in a one-sided way, making it yet another issue dividing Americans largely along
Publikováno v:
New England Journal of Medicine. 377:1213-1215
Providing ancillary care is sometimes obligatory in medical and health care studies. Its provision may, however, collide with achievement of a study’s aims. How should researchers respond when that happens?
Publikováno v:
New England Journal of Medicine. 377:505-507
Current prenatal screening practices and the complexity of genomic science create a risk that early, noninvasive fetal genetic sequencing will be integrated into care without the robust informed consent processes necessary for respecting women’s au
Publikováno v:
New England Journal of Medicine. 383:e130
Preterm Birth and 17OHP FDA withdrawal of the approval for 17OHP, as imperfect as the drug may be, will leave a very vulnerable demographic group of U.S. women at high risk for recurrent preterm bi...
Autor:
Pradip Dashraath, Yee-Chee Wong
Publikováno v:
New England Journal of Medicine. 383:1973-1973
Autor:
Calvin Q, Pan, Zhongping, Duan, Erhei, Dai, Shuqin, Zhang, Guorong, Han, Yuming, Wang, Huaihong, Zhang, Huaibin, Zou, Baoshen, Zhu, Wenjing, Zhao, Hongxiu, Jiang, Lei, Xiao
Publikováno v:
New England Journal of Medicine. 374:2324-2334
Few data are available regarding the use of tenofovir disoproxil fumarate (TDF) during pregnancy for the prevention of mother-to-child transmission of hepatitis B virus (HBV).In this trial, we included 200 mothers who were positive for hepatitis B e