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Autor:
Michael F. Greene, Caren G. Solomon
Publikováno v:
New England Journal of Medicine. 377:690-691
Not long after the physiological effects of prostacyclin (epoprostenol) and thromboxane on platelets and vessel walls were elucidated,1 it was suggested that many of the pathophysiological features of preeclampsia might be explained by disordered eic
Autor:
Lucinda England, Sharon Maynard, Vikas P. Sukhatme, Ravi Thadhani, Kai F. Yu, Franklin H. Epstein, Enrique F. Schisterman, Benjamin P. Sachs, Cong Qian, S. Ananth Karumanchi, Richard J. Levine, Kee-Hak Lim, Bahaeddine M Sibai
Publikováno v:
New England Journal of Medicine. 350:672-683
The cause of preeclampsia remains unclear. Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role.
Publikováno v:
New England Journal of Medicine. 346:33-38
The risk of preeclampsia is generally lower in second pregnancies than in first pregnancies, but not if the mother has a new partner for the second pregnancy. One explanation is that the risk is reduced with repeated maternal exposure and adaptation
Autor:
Caren G. Solomon, Ellen W. Seely
Publikováno v:
New England Journal of Medicine. 350:641-642
Three to 5 percent of pregnancies in the United States are complicated by preeclampsia, a multisystem disorder characterized by hypertension and proteinuria that occurs after 20 weeks of pregnancy. Preeclampsia is associated with substantial risks. F
Autor:
Lawrence M. Resnick, Phyllis A. Taufield, Joseph M. Gertner, Maurice L. Druzin, John H. Laragh, Kathy L. Ales
Publikováno v:
New England Journal of Medicine. 316:715-718
We studied 40 women in the third trimester of pregnancy to determine whether alterations in serum calcium levels or in urinary calcium excretion would distinguish patients with preeclampsia from normal pregnant women or women with other forms of gest
Publikováno v:
New England Journal of Medicine. 312:424-426
HEPATIC hemorrhage with rupture is a serious complication of preeclampsia with a high maternal and perinatal mortality, and the literature states that surgical intervention is indicated.1 , 2 Patie...