Zobrazeno 41 - 50
of 816
pro vyhledávání: ''
Autor:
Michael, Kozal, Judith, Aberg, Gilles, Pialoux, Pedro, Cahn, Melanie, Thompson, Jean-Michel, Molina, Beatriz, Grinsztejn, Ricardo, Diaz, Antonella, Castagna, Princy, Kumar, Gulam, Latiff, Edwin, DeJesus, Mark, Gummel, Margaret, Gartland, Amy, Pierce, Peter, Ackerman, Cyril, Llamoso, Max, Lataillade, A, Wurcel
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (13), pp.1232-1243. ⟨10.1056/nejmoa1902493⟩
New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (13), pp.1232-1243. ⟨10.1056/nejmoa1902493⟩
International audience; Background: Among some patients with human immunodeficiency virus type 1 (HIV-1) infection who have undergone multiple antiretroviral therapies and have limited options for treatment, new classes of antiretroviral drugs with n
Autor:
Lei Zhou, Jing Zhao, Guoqing Shi, Yang Yang, Gabriel M. Leung, Tian Liu, Xuhua Guan, Huan Li, Tommy Tsan-Yuk Lam, Zijian Feng, Qi Wang, Joseph T. Wu, Yeqing Tong, Dan Li, Benjamin J. Cowling, Rui Wang, Xiaoye Wang, Kathy Leung, Peng Wu, Zhongfa Tao, Suhua Zhou, Boxi Liu, Ruiqi Ren, Qun Li, Zhitao Ma, Rui Yang, Yuan Liu, Yingbo Luo, Zhiqiang Deng, Ge Shao, Wenxiao Tu, Hui Liu, Lianmei Jin, Yang Wu, Jessica Y. Wong, Man Liu, Nijuan Xiang, Chao Li, Chuding Chen, Eric H. Y. Lau, Yanping Zhang, Chen Qi, George F. Gao, Xuesen Xing, Bo Yang
Publikováno v:
New England Journal of Medicine
The New England Journal of Medicine
The New England Journal of Medicine
Background The initial cases of novel coronavirus (2019-nCoV)–infected pneumonia (NCIP) occurred in Wuhan, Hubei Province, China, in December 2019 and January 2020. We analyzed data on the first 425 confirmed cases in Wuhan to determine the epidemi
Autor:
Augusto A. Litonjua, Nancy Laranjo, Benjamin J. Stubbs, Vincent J. Carey, Robert S. Zeiger, Scott T. Weiss, Michael Schatz, Avraham Beigelman, Megan Sandel, Hooman Mirzakhani, Leonard B. Bacharier, Bruce W. Hollis, George T. O'Connor
Publikováno v:
N Engl J Med
BACKGROUND: We previously reported the results of a trial of prenatal vitamin D supplementation to prevent asthma and recurrent wheeze in young children, which suggested that supplementation provided a protective effect at the age of 3 years. We foll
Autor:
Jenny M. MacLennan, Peter Richmond, Jane Whelan, Adam Finn, Ray Borrow, Martin C. J. Maiden, Ann P. Koehler, Thomas Sullivan, Helen Marshall, Shamez N Ladhani, Andrew J Lawrence, Mark McMillan, Kumaran Vadivelu, Caroline Trotter, Mary Ramsay, Charlene M. Kahler
Publikováno v:
Marshall, H S, Lawrence, A, Trotter, C, Finn, A & al., E 2020, ' Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia ', New England Journal of Medicine, vol. 382, no. 4, pp. 318-327 . https://doi.org/10.1056/NEJMoa1900236
BACKGROUND: The meningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed to protect against invasive group B meningococcal disease. However, its role in preventing transmission and, therefore, inducing populat
Autor:
Tsimikas, Sotirios, Karwatowska-Prokopczuk, Ewa, Gouni-Berthold, Ioanna, Tardif, Jean-Claude, Baum, Seth J., Steinhagen-Thiessen, Elizabeth, Shapiro, Michael D., Stroes, Erik S., Moriarty, Patrick M., Nordestgaard, B. rge G., Xia, Shuting, Guerriero, Jonathan, Viney, Nicholas J., O'Dea, Louis, Witztum, Joseph L., Baum, Seth, Shapiro, Michael, Stroes, Erik, Moriarty, Patrick, Nordestgaard, B. rge, Gaudet, Daniel, Cuchel, Marina, Maron, David, Khandelwal, Abha, Klausen, Ib Christian, Rosenson, Robert, DeMaria, Anthony, Butman, Samuel, Weintraub, Howard, McPherson, Ruth, Koren, Michael, Bergeron, Jean, Ballantyne, Christie, DeFranco, Anthony, Aspry, Karen, Ahmed, Haitham, Andersen, Rolf, Hemphill, Linda, Shah, Prediman Krishan, Miller, Michael, Strader, Russell, Myerson, Merle, Thanassoulis, George
Publikováno v:
Tsimikas, S, Karwatowska-Prokopczuk, E, Gouni-Berthold, I, Tardif, J C, Baum, S J, Steinhagen-Thiessen, E, Shapiro, M D, Stroes, E S, Moriarty, P M, Nordestgaard, B G, Xia, S, Guerriero, J, Viney, N J, O'Dea, L & Witztum, J L 2020, ' Lipoprotein(a) Reduction in Persons with Cardiovascular Disease ', New England Journal of Medicine, vol. 382, no. 3, pp. 244-255 . https://doi.org/10.1056/NEJMoa1905239
New England journal of medicine, 382(3), 244-255. Massachussetts Medical Society
New England journal of medicine, 382(3), 244-255. Massachussetts Medical Society
BACKGROUND: Lipoprotein(a) levels are genetically determined and, when elevated, are a risk factor for cardiovascular disease and aortic stenosis. There are no approved pharmacologic therapies to lower lipoprotein(a) levels. METHODS: We conducted a r
Autor:
Hyung Kwan Kim, Sung-Ji Park, Cheol-Hyun Chung, Jaewon Lee, Dae-Hee Kim, Duk-Hyun Kang, Seungah Lee, Jong-Min Song, Jae-Kwan Song, Seung Woo Park, Geu Ru Hong, Sung-Cheol Yun, Sahmin Lee
Publikováno v:
New England Journal of Medicine. 382:111-119
The timing and indications for surgical intervention in asymptomatic patients with severe aortic stenosis remain controversial.In a multicenter trial, we randomly assigned 145 asymptomatic patients with very severe aortic stenosis (defined as an aort
Autor:
Anne A M W, van Kempen, P Frank, Eskes, Debbie H G M, Nuytemans, Johanna H, van der Lee, Lea M, Dijksman, Nicole R, van Veenendaal, Flip J P C M, van der Hulst, Rob M J, Moonen, Luc J I, Zimmermann, Ellen P, van 't Verlaat, Minouche, van Dongen-van Baal, Ben A, Semmekrot, Hélène G, Stas, Ron H T, van Beek, José J, Vlietman, Peter H, Dijk, Jacqueline U M, Termote, Rogier C J, de Jonge, Amerik C, de Mol, Marianne W A, Huysman, Joke H, Kok, Martin, Offringa, Nicole, Boluyt
Publikováno v:
New England Journal of Medicine, 382(6), 534. Massachussetts Medical Society
New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 382(6), 534-544. Massachussetts Medical Society
New England journal of medicine, 382(6), 534-544. Massachussetts Medical Society
Van Kempen, A A M W, Eskes, P F, Nuytemans, D H G M, Van Der Lee, J H, Dijksman, L M, Van Veenendaal, N R, Van Der Hulst, F J P C M, Moonen, R M J, Zimmermann, L J I, Van'T Verlaat, E P, Van Dongen-Van Baal, M, Semmekrot, B A, Stas, H G, Van Beek, R H T, Vlietman, J J, Dijk, P H, Termote, J U M, De Jonge, R C J, De Mol, A C, Huysman, M W A, Kok, J H, Offringa, M & Boluyt, N 2020, ' Lower versus traditional treatment threshold for neonatal hypoglycemia ', New England Journal of Medicine, vol. 382, no. 6, pp. 534-544 . https://doi.org/10.1056/NEJMoa1905593
Pediatric Neurology Briefs
New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine, 382(6), 534-544. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 382(6), 534-544. Massachussetts Medical Society
New England journal of medicine, 382(6), 534-544. Massachussetts Medical Society
Van Kempen, A A M W, Eskes, P F, Nuytemans, D H G M, Van Der Lee, J H, Dijksman, L M, Van Veenendaal, N R, Van Der Hulst, F J P C M, Moonen, R M J, Zimmermann, L J I, Van'T Verlaat, E P, Van Dongen-Van Baal, M, Semmekrot, B A, Stas, H G, Van Beek, R H T, Vlietman, J J, Dijk, P H, Termote, J U M, De Jonge, R C J, De Mol, A C, Huysman, M W A, Kok, J H, Offringa, M & Boluyt, N 2020, ' Lower versus traditional treatment threshold for neonatal hypoglycemia ', New England Journal of Medicine, vol. 382, no. 6, pp. 534-544 . https://doi.org/10.1056/NEJMoa1905593
Pediatric Neurology Briefs
BACKGROUND Worldwide, many newborns who are preterm, small or large for gestational age, or born to mothers with diabetes are screened for hypoglycemia, with a goal of preventing brain injury. However, there is no consensus on a treatment threshold t
Autor:
Shibadas, Biswal, Humberto, Reynales, Xavier, Saez-Llorens, Pio, Lopez, Charissa, Borja-Tabora, Pope, Kosalaraksa, Chukiat, Sirivichayakul, Veerachai, Watanaveeradej, Luis, Rivera, Felix, Espinoza, LakKumar, Fernando, Reynaldo, Dietze, Kleber, Luz, Rivaldo, Venâncio da Cunha, José, Jimeno, Eduardo, López-Medina, Astrid, Borkowski, Manja, Brose, Martina, Rauscher, Inge, LeFevre, Svetlana, Bizjajeva, Lulu, Bravo, Derek, Wallace, Zenaida, Mojares
Publikováno v:
New England Journal of Medicine. 381:2009-2019
Dengue, a mosquito-borne viral disease, was designated a World Health Organization top 10 threat to global health in 2019.We present primary efficacy data from part 1 of an ongoing phase 3 randomized trial of a tetravalent dengue vaccine candidate (T
Autor:
Alfred Mahr, Sue Cheng, Shannon McCue, Gulen Hatemi, Yusuf Yazici, Mitsuhiro Takeno, Yoshiaki Ishigatsubo, Mindy Chen, Do Young Kim, Melike Melikoglu, Maria Paris, Yeong Wook Song
Publikováno v:
New England Journal of Medicine. 381:1918-1928
The small-molecule phosphodiesterase 4 inhibitor apremilast modulates cytokines that are up-regulated in Behçet's syndrome. In a phase 2 trial involving patients with Behçet's syndrome, apremilast reduced the incidence and severity of oral ulcers.
Autor:
Claassens, Daniel M F, Vos, Gerrit J A, Bergmeijer, Thomas O, Hermanides, Renicus S, van 't Hof, Arnoud W J, van der Harst, Pim, Barbato, Emanuele, Morisco, Carmine, Tjon Joe Gin, Richard M, Asselbergs, Folkert W, Mosterd, Arend, Herrman, Jean-Paul R, Dewilde, Willem J M, Janssen, Paul W A, Kelder, Johannes C, Postma, Maarten J, de Boer, Anthonius, Boersma, Cornelis, Deneer, Vera H M, Ten Berg, Jurriën M, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology
Publikováno v:
New England Journal of Medicine, 381(17), 1621-1631. MASSACHUSETTS MEDICAL SOCIETY
New England Journal of Medicine, 381(17), 1621-1631. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine, 381, 1621. Massachussetts Medical Society
New England Journal of Medicine, 381(17), 1621. Massachussetts Medical Society
New England Journal of Medicine, 381(17), 1621-1631. MASSACHUSETTS MEDICAL SOC
New England Journal of Medicine, 381, 1621. Massachussetts Medical Society
New England Journal of Medicine, 381(17), 1621. Massachussetts Medical Society
BackgroundIt is unknown whether patients undergoing primary percutaneous coronary intervention (PCI) benefit from genotype-guided selection of oral P2Y(12) inhibitors.MethodsWe conducted a randomized, open-label, assessor-blinded trial in which patie