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Autor:
Fernando D. Martinez
Publikováno v:
New England Journal of Medicine. 375:871-878
The conventional thinking about COPD is that exposures in adult life, such as smoking, lead to a low FEV1:FVC ratio, the physiological hallmark of COPD. In this review, the effect of early-life exposures on the lung that could lead to expiratory airf
Autor:
Janice Canvin, Sunil Agarwal, Thomas B. Casale, Marcus Maurer, Ana Giménez-Arnau, Sarbjit S. Saini, Ramona Doyle, Allen P. Kaplan, Hsin-Ju Hsieh, Karin Rosén, Clive Grattan
Publikováno v:
New England Journal of Medicine. 368:924-935
Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses. In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody [corrected] that t
Autor:
Edmond J. FitzGibbon, John A. Butman, Michael T. Collins, Craig R. Dufresne, Pamela Gehron Robey, Janice S. Lee, Shlomo Wientroub, Harvey Kushner
Publikováno v:
New England Journal of Medicine. 347:1670-1676
Fibrous dysplasia of bone frequently involves the anterior base of the cranium and results in encasement of the optic-nerve canals. It has been assumed that such encasement leads to constriction and eventual blindness. There is controversy about whet
Autor:
Vincent L. Gott, Peter S. Greene, Diane E. Alejo, Duke E. Cameron, David C. Naftel, D. Craig Miller, A. Marc Gillinov, John C. Laschinger, Hans G. Borst, Christian E.A. Cabrol, Denton A. Cooley, Joseph S. Coselli, Tirone E. David, Randall B. Griepp, Nicholas T. Kouchoukos, Marko I. Turina, Reed E. Pyeritz
Publikováno v:
New England Journal of Medicine. 340:1307-1313
Replacement of the aortic root with a prosthetic graft and valve in patients with Marfan's syndrome may prevent premature death from rupture of an aneurysm or aortic dissection. We reviewed the results of this surgical procedure at 10 experienced sur
Publikováno v:
New England Journal of Medicine. 338:1174-1180
Corneal neurotrophic ulcers associated with impairment of sensory innervation of the cornea may lead to loss of vision, and there is no effective treatment for these ulcers. We evaluated the effects of nerve growth factor in patients with this disord
Autor:
Frederick R. Appelbaum, Paul J. Martin, Claudio Anasetti, Reginald A. Clift, Jerald P. Radich, Ted Gooley, Effie W. Petersdorf, Keith M. Sullivan, Rainer Storb, Thomas R. Chauncey, John A. Hansen, Jean E. Sanders
Publikováno v:
New England Journal of Medicine. 338:962-968
Chronic myeloid leukemia can be cured by marrow transplantation from an HLA-identical sibling donor. The use of transplants from unrelated donors is an option for the 70 percent of patients without an HLA-identical sibling, but the morbidity and mort
Autor:
Françoise Bernaudin, Sally C. Davies, Dana C. Matthews, Keith M. Sullivan, William C. Mentzer, Kwaku Ohene-Frempong, Mark C. Walters, M. Patience, Scott Jp, R Storb, Eckman, Wendy M. Leisenring
Publikováno v:
New England Journal of Medicine. 335:369-376
BACKGROUND We investigated the risks and benefits of allogeneic bone marrow transplantation in children with complications of sickle cell disease. METHODS Twenty-two children less than 16 years of age who had symptomatic sickle cell disease received
Autor:
Lawrence Y. Agodoa, Robert A. Wolfe, David W. Liska, Daniel S. Gaylin, Philip J. Held, Barry D. Kahan, Friedrich K. Port, Henry Krakauer, Jose R. Garcia, Lawrence G. Hunsicker
Publikováno v:
New England Journal of Medicine. 331:765-770
The benefits of HLA-A, B, and DR matching of cadaveric kidney grafts and recipients remain controversial when viewed from the perspective of social equity and graft survival.We estimated graft survival using proportional-hazards techniques, adjusting
Autor:
Suzan F. Murphy, Victor G. Dávila-Román, Johanna B. Perrillo, Thomas L. Spray, Nicholas T. Kouchoukos
Publikováno v:
New England Journal of Medicine. 330:1-6
The optimal substitute for severely diseased aortic valves in children and young adults is unknown. The use of a mechanical prosthesis requires permanent treatment of the patient with anticoagulants and is associated with thromboembolic and hemorrhag
Autor:
Nelson J. Chao, Gerhard M. Schmidt, Joyce C. Niland, Michael D. Amylon, Andrew C. Dagis, Gwynn D. Long, Auayporn P. Nademanee, Robert S. Negrin, Margaret R. O'Donnell, Pablo M. Parker, Eileen P. Smith, David S. Snyder, Anthony S. Stein, Ruby M. Wong, Karl G. Blume, Stephen J. Forman
Publikováno v:
New England Journal of Medicine. 329:1225-1230
Acute graft-versus-host disease (GVHD) following allogeneic bone marrow transplantation remains a serious problem. In a clinical trial, we tested the combination of cyclosporine and prednisone with and without methotrexate for the prevention of GVHD.