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pro vyhledávání: ''
Autor:
Michael E. Wechsler, Elliot Israel, Primal Kaur, Janet M. Griffiths, Christopher E. Brightling, Arnaud Bourdin, Andrew Menzies-gow, Gene L. Colice, Geoffrey Chupp, Gun Almqvist, Jonathan Corren, Karin Bowen, Sandhia Ponnarambil, Åsa Hellqvist
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
International audience; BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patient
Autor:
Donna Neuberg, Benjamin L. Ebert, R. Coleman Lindsley, Stephen R. Spellman, Peter V. Grauman, Katharine C. Hsu, Wael Saber, Corey Cutler, Michael D. Haagenson, Michael R. Verneris, Brenton G. Mar, Katharina Fleischhauer, Robert A. Redd, Joseph H. Antin, Zhen-Huan Hu, Stephanie J. Lee, Tao Wang
Publikováno v:
New England Journal of Medicine. 376:536-547
Genetic mutations drive the pathogenesis of the myelodysplastic syndrome (MDS) and are closely associated with clinical phenotype. Therefore, genetic mutations may predict clinical outcomes after allogeneic hematopoietic stem-cell transplantation.We
Autor:
Barbara Savoldo, Cliona M. Rooney, April G. Durett, David M. Spencer, Alana A. Kennedy-Nasser, Bambi Grilley, Conrad Russell Y. Cruz, Malcolm K. Brenner, Enli Liu, Gianpietro Dotti, Yuriko Fujita, Adrian P. Gee, Robert A. Krance, John Schindler, Karin Straathof, Hao Liu, Antonio Di Stasi, Caridad Martinez, Helen E. Heslop, Siok-Keen Tey
Publikováno v:
New England Journal of Medicine. 365:1673-1683
Cellular therapies could play a role in cancer treatment and regenerative medicine if it were possible to quickly eliminate the infused cells in case of adverse events. We devised an inducible T-cell safety switch that is based on the fusion of human
Autor:
Xinghuo Pang, Liang Miao, Xiaomei Li, Fujie Xu, Jiazi Zhangzhu, Luodan Suo, Xuechun Zhang, Min Lu, Weixiang Liu, Rui Ma, Li Lu, Yang Zeng, Wen-yan Ji, Ting Gao, Dong-lei Liu, Rui Yu, Jiang Wu, Ying Deng
Publikováno v:
New England Journal of Medicine. 363:2416-2423
BACKGROUND After the first monovalent 2009 pandemic influenza A (H1N1) vaccine became available in September 2009, Chinese officials conducted a mass vaccination program in Beijing. We evaluated the safety and effectiveness of the vaccine. METHODS Du
Autor:
Pei-Jer Chen, Barry E. Storer, Li Hui Tseng, Ming Tseh Lin, Ted Gooley, Paul J. Martin, John A. Hansen
Publikováno v:
New England Journal of Medicine. 349:2201-2210
Polymorphisms in cytokine genes can influence immune responses, inflammation, and tissue injury and may affect the outcome of hematopoietic stem-cell transplantation.We analyzed single-nucleotide polymorphisms in the genes for interleukin-1beta, inte
Autor:
Mary Grace Stobierski, Lisa N. Pealer, Kimberly Signs, Peter L Page, Jesse L. Goodman, Robert S. Lanciotti, Bruce Newman, Susan L. Stramer, Anthony A. Marfin, Lyle R. Petersen, Mary E. Chamberland, Hema Kapoor
Publikováno v:
New England Journal of Medicine. 349:1236-1245
During the 2002 West Nile virus epidemic in the United States, patients were identified whose West Nile virus illness was temporally associated with the receipt of transfused blood and blood components.Patients with laboratory evidence of recent West
Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia
Autor:
Ching-Hon Pui, Raul C. Ribeiro, Michael L. Hancock, Gaston K. Rivera, William E. Evans, Susana C. Raimondi, David R. Head, Frederick G. Behm, M. Hazem Mahmoud, John T. Sandlund, William M. Crist
Publikováno v:
New England Journal of Medicine. 325:1682-1687
Treatment of cancer with the epipodophyllotoxins (etoposide and teniposide) has been linked to the development of acute myeloid leukemia (AML) in children and adults, but the factors that might influence the risk of this complication of therapy are p
Autor:
Alain Fischer, Stéphane Blanche, Jérôme Le Bidois, Pierre Bordigoni, Jane Luce Garnier, Patrick Niaudet, Frederic Morinet, Françoise Le Deist, Anne-Marie Fischer, Claude Griscelli, Michel Hirn
Publikováno v:
New England Journal of Medicine. 324:1451-1456
The B-cell lymphoproliferative syndrome is an infrequent life-threatening complication of marrow or organ transplantation that is the consequence of profound immunosuppression. The results of treatment have been disappointing, although a small number
Autor:
Sharon M. Baker, Carel Mulder, John L. Sullivan, Peter G. Medveczky, Monroe J, Stephen J. Forman
Publikováno v:
New England Journal of Medicine. 311:1163-1167
EPSTEIN–BARR virus (EBV), a transforming herpesvirus that infects and replicates in B lymphocytes, is being increasingly recognized as a cause of lymphoproliferative disorders in immunodeficient hosts. Males with the X-linked lymphoproliferative sy
Autor:
K. Schimpf, P.M. Mannucci, W. Kreutz, H.H. Bragkmann, C. Auerswald, N. Ciavarella, J. Mösseler, V. DeRosa, B. Kraus, Ch. Bruegkmann, G. Mancuso, U. Mittler, F. Haschke, M. Morfini
Publikováno v:
New England Journal of Medicine. 316:918-922
Post-transfusion hepatitis is frequent among patients with hemophilia who are treated with concentrated factor VIII prepared from pooled plasma, especially if it is obtained from paid donors. In 26 patients with hemophilia A or von Willebrand's disea