Zobrazeno 1 - 10
of 18
pro vyhledávání: ''
Autor:
Kevan C, Herold, Brian N, Bundy, S Alice, Long, Jeffrey A, Bluestone, Linda A, DiMeglio, Matthew J, Dufort, Stephen E, Gitelman, Peter A, Gottlieb, Jeffrey P, Krischer, Peter S, Linsley, Jennifer B, Marks, Wayne, Moore, Antoinette, Moran, Henry, Rodriguez, William E, Russell, Desmond, Schatz, Jay S, Skyler, Eva, Tsalikian, Diane K, Wherrett, Anette-Gabriele, Ziegler, Carla J, Greenbaum, Stuart, Weinzimer
Publikováno v:
The New England journal of medicine, vol 381, iss 7
BackgroundType 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival. Some interventions have delayed the loss of insulin production in patients with type
Autor:
Ninette Amariglio, Atar Lev, Christoph Klein, Kevin Bishop, James C. Mullikin, Tatiana Babushkin, Tomas Racek, Raman Sood, Thierry Vilboux, Baruch Wolach, Ronit Gavrieli, Andrew R. Cullinane, Blake Carrington, Amos J. Simon, Yair Anikster, Päivi M Järvinen, Ben Zion Garty, Iris Barshack, Sylvie Polak-Charcon, Gideon Rechavi, William A. Gahl, Eran Eyal, Jutte van der Werff ten Bosch, Raz Somech, Amos Toren, Marjan Huizing, Osama M. Atawneh, May Christine V. Malicdan, Ginette Schiby, Jacek Puchałka, Michalle Soudack, Camila Avivi
Publikováno v:
New England Journal of Medicine. 369:54-65
BACKGROUND: Neutrophils are the predominant phagocytes that provide protection against bacterial and fungal infections. Genetically determined neutrophil disorders confer a predisposition to severe infections and reveal novel mechanisms that control
Autor:
Klaus Bønnelykke, Carole Ober, Michelle M. Stein, Gaixin Du, Dan L. Nicolae, James E. Gern, Hans Bisgaard, R.F. Lemanske, Daniel J. Jackson, Yury A. Bochkov, Eskil Kreiner-Møller, Minal Çalışkan
Publikováno v:
New England Journal of Medicine. 368:1398-1407
BACKGROUND Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing illnesses are associated with the development of asthma. Our aim was to determine the effects of these two factors on the risk of asthma in the Childhood Orig
Autor:
Barbara S. Adams, Frank Pucino, Natalie J Dailey, Richard K. Vehe, Leonard D. Stein, James N. Jarvis, Christopher K. Zalewski, Christopher Snyder, Bracha Shaham, Robert Wesley, Philip N. Hawkins, Kathleen M. O'Neil, Ivona Aksentijevich, T. Pham, Scott W. Canna, William Horn, Steven C. Hoffmann, Robert W. Warren, Maria L. Turner, Suvimol Hill, Carmen C. Brewer, Janet Jones, Laurie O Beitz, Joe L Cole, John A. Butman, Scott M. Paul, Margje H. Haverkamp, Scott R. Penzak, Raphaela Goldbach-Mansky, Gregory C. Gardner, H. Jeffrey Kim, Steven M. Holland, Robert C. Fuhlbrigge, Daniel L. Kastner, Terry L. Moore, Barbara I. Karp, Edythe Wiggs, Benjamin I. Rubin, Ana Gelabert, William P Hannan
Publikováno v:
New England Journal of Medicine. 355:581-592
Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1
Autor:
Marianna Wilson, Jose Munoz, Alan M. Aron, Ana Flisser, Peter M. Schantz, Barry J. Hartman, Elsa Sarti, Anne C. Moore, John A. Schaefer, Deborah Persaud
Publikováno v:
New England Journal of Medicine. 327:692-695
From June 1990 through July 1991, intracerebral infection with the larval stage of the pork tapeworm Taenia solium was diagnosed in four unrelated persons in an Orthodox Jewish community in New York City. None of the patients had eaten pork, and only
Publikováno v:
New England Journal of Medicine. 295:1385-1390
Neutrophil production and distribution were studied in two families with autosomal dominantly inherited neutropenia to distinguish their illness from other neutropenic disorders. In addition to a reduced post-mitotic pool of bone-marrow neutrophils a
Autor:
Charles Drummond, Mark H. Skolnick, David E. Goldgar, Linda M. Griffen, Corwin Q. Edwards, James P. Kushner
Publikováno v:
New England Journal of Medicine. 318:1355-1362
There is evidence that iron loading and organ damage can be prevented in patients with hemochromatosis if prophylactic phlebotomy is employed early in the disease--findings emphasizing the importance of early detection before clinical signs occur. Th
Autor:
Douglas B. Cines, Alan D. Schreiber
Publikováno v:
New England Journal of Medicine. 300:106-111
We applied a radiolabeled Coombs antiglobulin test to the diagnosis and management of immune thrombocytopenia in adults and children. This assay substantiated that the majority of patients with idiopathic thrombocytopenic purpura have increased level
Autor:
Carole Beaumont, Renée Fauchet, Jean-Pierre Hespel, Marcel Simon, Michel Bourel, Bernard Genetet, Pierre Brissot
Publikováno v:
New England Journal of Medicine. 301:169-174
To determine whether a correlation exists between the biochemical expression of hemochromatosis and the HLA genotype, we studied 174 family members of 32 persons with the disease. Persons who shared both HLA haplotypes with the proband (and presumabl
Autor:
Arthur R. Spielvogel, Dawn T. Pei, Ralph C. Marcove, Edward Essner, Bijay Mukherji, Yashar Hirshaut
Publikováno v:
New England Journal of Medicine. 291:1103-1107
A previously identified tumor-associated antigen of human sarcomas, S1, has been studied to characterize further its association with neoplasia. We used an immunofluorescence test on 166 serum specimens from normal persons and 295 from patients with