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Autor:
Carlos Richard, Adalberto Benito, Cristina Sanz, Jose L. Fernandez-Luna, I Olalla, Maite Silva
Publikováno v:
New England Journal of Medicine. 338:564-571
Deregulating the expression of Bcl-xL, an inhibitor of apoptosis, in an erythropoietin-dependent erythroblast cell line averts apoptosis induced by the withdrawal of erythropoietin. Since in polycythemia vera an abnormal clone of erythroid progenitor
Autor:
Theodore F. Zipf, Dennis A. Johnston, Maia V. Ouspenskaia, Zeev Estrov, William Mark Roberts, Kenneth L. McClain
Publikováno v:
New England Journal of Medicine. 336:317-323
Complete remission of B-precursor acute lymphoblastic leukemia (ALL) has traditionally been defined as the near absence of lymphoblasts in a light-microscopical examination of stained bone marrow smears, but a patient in remission may still harbor up
Publikováno v:
New England Journal of Medicine. 333:487-493
In severe congenital neutropenia the maturation of myeloid progenitor cells is arrested. The myelodysplastic syndrome and acute myeloid leukemia develop in some patients with severe congenital neutropenia. Abnormalities in the signal-transduction pat
Autor:
Michael L. Hancock, John T. Sandlund, Frederick G. Behm, Gaston K. Rivera, Raul C. Ribeiro, Robert A. Krance, William M. Crist, Larry E. Kun, Ching-Hon Pui, Hazem Mahmoud
Publikováno v:
New England Journal of Medicine. 329:314-319
Treatment of the central nervous system is crucial to the successful treatment of acute lymphoblastic leukemia in children. The intensity and timing of the therapy are based on the presence or predicted risk of central nervous system leukemia as asse
Publikováno v:
New England Journal of Medicine. 303:421-425
The therapeutic efficacy of prothrombin-complex concentrates in patients with hemophilia and inhibitors (antibodies) to factor VIII has been increasingly debated. We therefore entered 51 hemophiliacs with factor VIII inhibitors into a double-blind ra
Publikováno v:
New England Journal of Medicine. 300:1374-1377
SINCE leukemic cells express certain cell-surface markers common to normal human lymphocytes, acute lymphoblastic leukemia can be differentiated immunologically into T-cell, B-cell and null (non-T,...
Autor:
Lois W. Dow, John W. Adamson, Jack W. Singer, Philip J. Fialkow, Robert Veith, Irwin D. Bernstein, Wendy H. Raskind, Robert Jacobson, Vesna Najfeld
Publikováno v:
New England Journal of Medicine. 317:468-473
To determine whether acute nonlymphocytic leukemia develops clonally, to study the pattern of differentiation of the involved stem cells, and to determine whether clinical remissions are true remissions, we studied 27 patients with acute nonlymphocyt
Autor:
David Emanuel, Constance Cirrincione, Richard J. O'Reilly, Brenda Shank, Nancy A. Kernan, Joseph Laver, Susan Groshen, Joel A. Brochstein
Publikováno v:
New England Journal of Medicine. 317:1618-1624
Ninety-seven children with either acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML) received HLA-identical bone marrow transplants from sibling donors, after preparation with 1320 cGy of hyperfractionated total-body irradiation a
Publikováno v:
New England Journal of Medicine. 281:923-926
Observation of Howell—Jolly bodies in the blood of children with sickle-cell anemia suggested the paradox of splenic hypofunction despite clinical splenomegaly. Spleen scans were performed with a sulfur colloid tagged with radioactive technetium (9
Publikováno v:
New England Journal of Medicine. 272:761-766
MEDIASTINAL-lymph-node hyperplasia resembling thymoma was first recognized as an entity by Castleman in 1954,1 although 3 cases of "enlarged inflammatory lymph nodes" had previously been described in 1946,2 in a series of 109 patients operated on for