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Publikováno v:
New England Journal of Medicine. 320:881-886
The incidence rate of insulin-dependent (Type I) diabetes mellitus is bimodal: one peak occurs close to puberty, and the other in the fifth decade. To evaluate possible differences in these forms of the disease, we examined the clinical, biochemical,
Autor:
Nancy Gutensohn, Philip A. Cole
Publikováno v:
New England Journal of Medicine. 304:135-140
The epidemiologic similarities between Hodgkin's disease in the young and paralytic poliomyelitis suggest that Hodgkin's disease may be a rare consequence of a common infection, with the probability of oncogenesis increasing with age at the time of i
Autor:
Nicholas J. Vianna, Adele K. Polan
Publikováno v:
New England Journal of Medicine. 289:499-502
To evaluate the possible role of horizontal transmission in Hodgkin's disease, we tested the hypothesis that where a case had occurred in a teacher or student from 1960 through 1970, more than the expected number of additional cases would appear amon
Publikováno v:
New England Journal of Medicine. 299:1428-1435
The protective role and underlying sources of the elevated levels of fetal hemoglobin associated with sickle-cell anemia were reassessed by microscopical immunodiffusion assays. Three variables that contribute to levels of fetal hemoglobin were exami
Publikováno v:
New England Journal of Medicine. 318:76-81
We estimated the risk of second cancers among 1507 patients with Hodgkin's disease treated at Stanford University Medical Center since 1968. Eight-three second cancers occurred more than one year after diagnosis, as compared with 15.9 expected on the
Publikováno v:
New England Journal of Medicine. 298:607-612
FOR centuries before the introduction of the thermometer, fever was a well recognized sign of disease. During the Age of Pericles (ca. 450 B.C.) physicians accurately described the physical findings associated with the fevers of typhoid and other inf
Publikováno v:
New England Journal of Medicine. 301:1212-1222
During the past two decades, new approaches to the diagnosis and treatment of Hodgkin's disease have contributed to improved rates of survival and probable cure. Currently, patients with Hodgkin's disease are treated according to the stage and sympto
Autor:
Stanley M. Lemon
Publikováno v:
New England Journal of Medicine. 313:1059-1067
IN recent years, our understanding of the nature and diversity of viruses causing hepatitis in human beings has been sharply increased.1 Those agents now include the viruses of hepatitis A (classic short-incubation infectious hepatitis) and hepatitis
Autor:
Maria T. Rojeski, Hossein Gharib
Publikováno v:
New England Journal of Medicine. 313:428-436
Thyroid nodules continue to be a source of concern to patients, and their management remains a controversy among physicians. Several diagnostic techniques have been proposed to distinguish benign nodules (the majority) from malignant lesions (the min
Autor:
Joel G. Breman, Isao Arita
Publikováno v:
New England Journal of Medicine. 303:1263-1273
In December 1979, an independent scientific commission certified global eradication of smallpox. This conclusion was accepted at the 33d World Health Assembly of the World Health Organization (WHO) in May 1980. After WHO'S intensified eradication pro