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Autor:
Julie R. Ingelfinger
Publikováno v:
New England Journal of Medicine. 350:2123-2126
Hypertension, which is common among adults in the United States, has for several decades been recognized as a cardiovascular risk factor. Since blood pressure tends to “track” along the same percen...
Publikováno v:
New England Journal of Medicine. 326:1727-1732
BACKGROUND Previous studies of renal transplantation in children have focused on the survival of grafts and patients. Little information is available about the cause of renal disease, the sources of donated organs, or children's growth after transpla
Publikováno v:
New England Journal of Medicine. 325:1349-1353
Bone marrow transplantation has been shown to cure sickle cell disease, but it carries a 15 percent mortality risk. To determine whether parents would accept this risk to cure their children of sickle cell disease, we interviewed parents of children
Autor:
Bruce K. Rubin
Publikováno v:
New England Journal of Medicine. 323:782-788
In children, passive exposure to environmental tobacco smoke has been associated with growth suppression and an increased frequency of respiratory tract infections. On the assumption that this association would be more pronounced in children with chr
Systemic Exposure to Mercaptopurine as a Prognostic Factor in Acute Lymphocytic Leukemia in Children
Autor:
Gideon Koren, Stephen Soldin, Gianmario Ferrazini, Ester Giesbrecht, Mark L. Greenberg, Anne-Marie R Langevin, Hassan Sulh, Joseph Kapelushnik, Julia Klein
Publikováno v:
New England Journal of Medicine. 323:17-21
Despite a success rate of more than 90 percent in inducing remission in children with acute lymphocytic leukemia, 30 to 40 percent of such children relapse. Maintenance therapy during remission usually includes oral mercaptopurine and methotrexate. R
Publikováno v:
New England Journal of Medicine. 320:881-886
The incidence rate of insulin-dependent (Type I) diabetes mellitus is bimodal: one peak occurs close to puberty, and the other in the fifth decade. To evaluate possible differences in these forms of the disease, we examined the clinical, biochemical,