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Autor:
Stanley R. Hamilton, Linda M. Hylind, Gloria M. Petersen, Francis M. Giardiello, Rodger D. Parker, Judith A. Bacon, Jill D. Brensinger, Michael C. Luce, Susan V. Booker
Publikováno v:
New England Journal of Medicine. 336:823-827
The use of commercially available tests for genes linked to familial cancer has aroused concern about the impact of these tests on patients. Familial adenomatous polyposis is an autosomal dominant disease caused by a germ-line mutation of the adenoma
Autor:
Earl R. Kern, Spotswood L. Spruance, Gerald G. Krueger, Victoria Pliam, James C. Overall, William C. Miller
Publikováno v:
New England Journal of Medicine. 297:69-75
We performed daily examination of 80 patients with recurrent herpes simplex labialis to define the course of the disease and to identify quantitative and objective measurements for use in monitoring the efficacy of antiviral chemotherapy. Pain, lesio
Autor:
Cage S. Johnson, Ralph Carmel
Publikováno v:
New England Journal of Medicine. 298:647-650
Pernicious anemia affects primarily elderly northern Europeans, but may affect others more often than previously thought. Therefore, we analyzed the data from 156 documented cases: there were 73 patients of "European" origin, 52 black patients and 31
Autor:
Arthur R. Spielvogel, Dawn T. Pei, Ralph C. Marcove, Edward Essner, Bijay Mukherji, Yashar Hirshaut
Publikováno v:
New England Journal of Medicine. 291:1103-1107
A previously identified tumor-associated antigen of human sarcomas, S1, has been studied to characterize further its association with neoplasia. We used an immunofluorescence test on 166 serum specimens from normal persons and 295 from patients with
Autor:
Gordon T. Moore, Marshall S. Horwitz
Publikováno v:
New England Journal of Medicine. 279:399-404
An outbreak of acute infectious lymphocytosis (white-cell counts of 26,000 to 93,800) was studied in 27 children at a state school for the mentally retarded. The search for an etiology of the disease included infectious and noninfectious agents. Exam
Publikováno v:
New England Journal of Medicine. 270:870-874
THE effectiveness of artificial immunization in preventing influenza has been difficult to evaluate. A reduction in the incidence of disease occurs when inactivated vaccines containing the antigen of the prevalent type of influenza are applied before
Autor:
James B. Hanshaw
Publikováno v:
New England Journal of Medicine. 275:476-479
THE report with Weller, in 1962, of microcephaly in 14 of 17 infants with generalized cytomegalic inclusion disease established the association of this Central-nervous-system defect with intrauterine cytomegalovirus infection.1 In 1964 Medearis2 demo
Publikováno v:
New England Journal of Medicine. 292:621-623
THE nearly universal association of Epstein–Barr virus (EBV) with African Burkitt's lymphoma has been established by serologic procedures,1 demonstration of viral DNA in tumor biopsies by nucleic a...
Autor:
Thomas Ed
Publikováno v:
New England Journal of Medicine. 312:46-48
It was first shown in rodents that the use of a marrow-graft donor matched at the major histocompatibility complex reduced the incidence and severity of graft-versus-host disease and considerably i...