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pro vyhledávání: ''
Autor:
Chunqin Deng, Leigh Peterson, Kristan Rollins, Roblee P Allen, Rahul G. Argula, Heidi Bell, Aaron B. Waxman, Abubakr Bajwa, Steven D. Nathan, Pete Smith, Ashwin Ravichandran, Jeremy Feldman, Victor F. Tapson, Ricardo Restrepo-Jaramillo, Peter A. Engel, Thenappan Thenappan
Publikováno v:
New England Journal of Medicine. 384:325-334
No therapies are currently approved for the treatment of pulmonary hypertension in patients with interstitial lung disease. The safety and efficacy of inhaled treprostinil for patients with this condition are unclear.We enrolled patients with interst
Autor:
Ken, Okumura, Masaharu, Akao, Tetsuro, Yoshida, Masahito, Kawata, Osamu, Okazaki, Shintaro, Akashi, Kenichi, Eshima, Kimihiko, Tanizawa, Masayuki, Fukuzawa, Takuya, Hayashi, Masahiro, Akishita, Gregory Y H, Lip, Takeshi, Yamashita
Publikováno v:
Okumura, K, Akao, M, Yoshida, T, Kawata, M, Okazaki, O, Akashi, S, Eshima, K, Tanizawa, K, Fukuzawa, M, Hayashi, T, Akishita, M, Lip, G Y H & Yamashita, T 2020, ' Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation ', New England Journal of Medicine, vol. 383, no. 18, pp. 1735-1745 . https://doi.org/10.1056/NEJMoa2012883
BACKGROUND: Implementation of appropriate oral anticoagulant treatment for the prevention of stroke in very elderly patients with atrial fibrillation is challenging because of concerns regarding bleeding. METHODS: We conducted a phase 3, multicenter,
Autor:
Sheila O, Martins, Francisco, Mont'Alverne, Letícia C, Rebello, Daniel G, Abud, Gisele S, Silva, Fabrício O, Lima, Bruno S M, Parente, Guilherme S, Nakiri, Mário B, Faria, Michel E, Frudit, João J F, de Carvalho, Eduardo, Waihrich, José A, Fiorot, Fabrício B, Cardoso, Raquel C T, Hidalgo, Viviane F, Zétola, Fernanda M, Carvalho, Ana C, de Souza, Francisco A, Dias, Diego, Bandeira, Maramélia, Miranda Alves, Mário B, Wagner, Leonardo A, Carbonera, Jamary, Oliveira-Filho, Daniel C, Bezerra, David S, Liebeskind, Joseph, Broderick, Carlos A, Molina, José E, Fogolin Passos, Jeffrey L, Saver, Octávio M, Pontes-Neto, Raul G, Nogueira, Glayse, Gabriel
Publikováno v:
New England Journal of Medicine. 382:2316-2326
Randomized trials involving patients with stroke have established that outcomes are improved with the use of thrombectomy for large-vessel occlusion. These trials were performed in high-resource countries and have had limited effects on medical pract
Autor:
Mandeep R, Mehra, Nir, Uriel, Yoshifumi, Naka, Joseph C, Cleveland, Melana, Yuzefpolskaya, Christopher T, Salerno, Mary N, Walsh, Carmelo A, Milano, Chetan B, Patel, Steven W, Hutchins, John, Ransom, Gregory A, Ewald, Akinobu, Itoh, Nirav Y, Raval, Scott C, Silvestry, Rebecca, Cogswell, Ranjit, John, Arvind, Bhimaraj, Brian A, Bruckner, Brian D, Lowes, John Y, Um, Valluvan, Jeevanandam, Gabriel, Sayer, Abeel A, Mangi, Ezequiel J, Molina, Farooq, Sheikh, Keith, Aaronson, Francis D, Pagani, William G, Cotts, Antone J, Tatooles, Ashok, Babu, Don, Chomsky, Jason N, Katz, Paul B, Tessmann, David, Dean, Arun, Krishnamoorthy, Joyce, Chuang, Ia, Topuria, Poornima, Sood, Daniel J, Goldstein, Ahmet, Kilic
Publikováno v:
New England Journal of Medicine. 380:1618-1627
In two interim analyses of this trial, patients with advanced heart failure who were treated with a fully magnetically levitated centrifugal-flow left ventricular assist device were less likely to have pump thrombosis or nondisabling stroke than were
Autor:
John Alexander, Jose Nicolau, Olga Godlevska, Valentyn Maslovskyi, Piotr Feusette, Tamina Levy, António Gaspar, Robert Storey, Julio Núñez, Maria Christiane Valeria Braga Braile-Sternieri, Sotir Marchev, Yury Shvarts, Sakac, Joerg Strobel, Diana Gorog, Elena Kosmacheva, Daniel Scherr, Peter Sinnaeve, Lars Maier, WILLIAM HEDDLE, Grishaev S.L., Oleg Averkov, Jan Fedacko, Daniel Pella, Ivo Petrov, Sergei Shalaev, Amos Katz, Meyer ELBAZ, Ziad Hijazi, Viktor Tashchuk, Svetlana Boldueva, Francesco Costa, Fausto J. Pinto, Jerzy Wranicz, Adrian Wlodarczak, David Brieger, Peter Nordbeck, Rodrigo Bagur, Andrzej Budaj
Publikováno v:
The New England journal of medicine, Vol. 380, no. 16, p. 1509-1524 (2019)
Background: Appropriate antithrombotic regimens for patients with atrial fibrillation who have an acute coronary syndrome or have undergone percutaneous coronary intervention (PCI) are unclear. Methods: In an international trial with a two-by-two fac
Autor:
P.M. Steijlen, Patty J. Nelemans, Aimee H.M.M. Arits, Klara Mosterd, Nina Kouloubis, J.P.H.M. Kessels, Nicole W.J. Kelleners-Smeets, Han P. A. van Pelt, Patricia J. F. Quaedvlieg, Maud H.E. Jansen, Brigitte A. B. Essers
Publikováno v:
New England Journal of Medicine, 380(10), 935-946. MASSACHUSETTS MEDICAL SOCIETY
BACKGROUNDActinic keratosis is the most frequent premalignant skin disease in the white population. In current guidelines, no clear recommendations are made about which treatment is preferred.METHODSWe investigated the effectiveness of four frequentl
Autor:
John J, McNeil, Mark R, Nelson, Robyn L, Woods, Jessica E, Lockery, Rory, Wolfe, Christopher M, Reid, Brenda, Kirpach, Raj C, Shah, Diane G, Ives, Elsdon, Storey, Joanne, Ryan, Andrew M, Tonkin, Anne B, Newman, Jeff D, Williamson, Karen L, Margolis, Michael E, Ernst, Walter P, Abhayaratna, Nigel, Stocks, Sharyn M, Fitzgerald, Suzanne G, Orchard, Ruth E, Trevaks, Lawrence J, Beilin, Geoffrey A, Donnan, Peter, Gibbs, Colin I, Johnston, Barbara, Radziszewska, Richard, Grimm, Anne M, Murray, A, Zwijnenburg
Publikováno v:
New England Journal of Medicine. 379:1519-1528
BACKGROUND: In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-fr
Autor:
John J, McNeil, Robyn L, Woods, Mark R, Nelson, Christopher M, Reid, Brenda, Kirpach, Rory, Wolfe, Elsdon, Storey, Raj C, Shah, Jessica E, Lockery, Andrew M, Tonkin, Anne B, Newman, Jeff D, Williamson, Karen L, Margolis, Michael E, Ernst, Walter P, Abhayaratna, Nigel, Stocks, Sharyn M, Fitzgerald, Suzanne G, Orchard, Ruth E, Trevaks, Lawrence J, Beilin, Geoffrey A, Donnan, Peter, Gibbs, Colin I, Johnston, Joanne, Ryan, Barbara, Radziszewska, Richard, Grimm, Anne M, Murray, M, Mercado
Publikováno v:
New England Journal of Medicine. 379:1499-1508
BACKGROUND: Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear. METHODS: From 2010
Autor:
Jonathan Bodansky, Colin Baigent, Richard Peto, Allen Young, Rory Collins, Emily L. Sammons, Aleksandra Murawska, Andrew Farmer, K Wallendszus, Sarah Parish, Andrew Neil, Georgina Buck, William M. Stevens, Roger McPherson, David Simpson, Kevin T. Murphy, Emma Waters, Jolyon Cox, Jill Barton, Fang Chen, Richard Haynes, Theingi Aung, Michael Lay, Louise Bowman, Jane Armitage, Marion Mafham, Amanda I Adler
Publikováno v:
New England Journal of Medicine. 379:1529-1539
Background Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first
Autor:
Joseph D. Szustakowski, Prabhu Bhagavatheeswaran, Adam Pluzanski, Hossein Borghaei, George Green, Yali Fu, Julie R. Brahmer, Clarisse Audigier-Valette, Kenneth J. O'Byrne, Jong-Seok Lee, Pamela Salman, Luis Paz-Ares, William J. Geese, Diane Healey, Helena Linardou, Sjaak Burgers, Elisa Minenza, Martin Reck, Matthew D. Hellmann, Han Chang, Gregory A. Otterson, F. E. Nathan, Suresh S. Ramalingam, Tudor-Eliade Ciuleanu
Publikováno v:
N Engl J Med
BACKGROUND: Nivolumab plus ipilimumab showed promising efficacy for the treatment of non-small-cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit. In this part of an open-label, mu