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pro vyhledávání: '"Ragini Kudchadkar"'
Autor:
Peng Sun, Kevin B. Kim, Howard A. Burris, Omid Hamid, Jeffrey A. Sosman, Jonathan Cebon, Alicia Allred, Peter F. Lebowitz, Gerald S. Falchook, Richard F. Kefford, Karl D. Lewis, Daniele Ouellet, Keith T. Flaherty, J. R. Infante, Lynn M. Schuchter, Adil Daud, Rene Gonzalez, Georgina V. Long, Jeffrey S. Weber, Nageatte Ibrahim, Igor Puzanov, Ragini Kudchadkar, Ajay Singh, Alain Algazi, Shonda M Little, Kiran Patel
Publikováno v:
The New England journal of medicine, vol 367, iss 18
BackgroundResistance to therapy with BRAF kinase inhibitors is associated with reactivation of the mitogen-activated protein kinase (MAPK) pathway. To address this problem, we conducted a phase 1 and 2 trial of combined treatment with dabrafenib, a s