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pro vyhledávání: ''
Autor:
Michael E. Wechsler, Elliot Israel, Primal Kaur, Janet M. Griffiths, Christopher E. Brightling, Arnaud Bourdin, Andrew Menzies-gow, Gene L. Colice, Geoffrey Chupp, Gun Almqvist, Jonathan Corren, Karin Bowen, Sandhia Ponnarambil, Åsa Hellqvist
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
International audience; BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patient
Autor:
Wei-Jie, Guan, Zheng-Yi, Ni, Yu, Hu, Wen-Hua, Liang, Chun-Quan, Ou, Jian-Xing, He, Lei, Liu, Hong, Shan, Chun-Liang, Lei, David S C, Hui, Bin, Du, Lan-Juan, Li, Guang, Zeng, Kwok-Yung, Yuen, Ru-Chong, Chen, Chun-Li, Tang, Tao, Wang, Ping-Yan, Chen, Jie, Xiang, Shi-Yue, Li, Jin-Lin, Wang, Zi-Jing, Liang, Yi-Xiang, Peng, Li, Wei, Yong, Liu, Ya-Hua, Hu, Peng, Peng, Jian-Ming, Wang, Ji-Yang, Liu, Zhong, Chen, Gang, Li, Zhi-Jian, Zheng, Shao-Qin, Qiu, Jie, Luo, Chang-Jiang, Ye, Shao-Yong, Zhu, Nan-Shan, Zhong
Publikováno v:
New England Journal of Medicine
Perm J
Perm J
Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.We extracted data regarding 1099 patients with lab
Autor:
Minna Pekkinen, Outi Mäkitie, Terhi J. Heino, Lisette Nevarez, Cynthia J. Curry, Christine M. Laine, Heikki Kröger, Mira Aronen, Kyu Sang Joeng, Maija Wessman, Daniel H. Cohn, Brendan Lee, Deborah Krakow, Philippe M. Campeau, James T. Lu, William G. Cole, Richard A. Gibbs, Monica Grover, Riku Kiviranta, Tero Laine, Vappu Nieminen-Pihala, Kati Tarkkonen, Anna-Elina Lehesjoki
Publikováno v:
New England Journal of Medicine. 368:1809-1816
This report identifies human skeletal diseases associated with mutations in WNT1. In 10 family members with dominantly inherited, early-onset osteoporosis, we identified a heterozygous missense mutation in WNT1, c.652T→G (p.Cys218Gly). In a separat
Autor:
Janice Canvin, Sunil Agarwal, Thomas B. Casale, Marcus Maurer, Ana Giménez-Arnau, Sarbjit S. Saini, Ramona Doyle, Allen P. Kaplan, Hsin-Ju Hsieh, Karin Rosén, Clive Grattan
Publikováno v:
New England Journal of Medicine. 368:924-935
Many patients with chronic idiopathic urticaria (also called chronic spontaneous urticaria) do not have a response to therapy with H-antihistamines, even at high doses. In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody [corrected] that t
Autor:
Ross McManus, Neil Walker, Patrick Dubois, Cisca Wijmenga, Kate Downes, Graham A. Heap, Joanna M. M. Howson, David A. van Heel, Karen A. Hunt, Jason D. Cooper, Vincent Plagnol, John A. Todd, David Clayton, Jennie H M Yang, Helen Stevens, Deborah J. Smyth
Publikováno v:
New England Journal of Medicine, 359(26), 2767-2777. MASSACHUSETTS MEDICAL SOC
Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shar
Autor:
Christine G. Allison, Shelley L. Murray, Joe McLaughlin, Cheryl A. Bopp, Karen A. Martinek, Angelo DePaola, Michele M. Bird, John P. Middaugh, Nancy P. Napolilli, Eric C. Thompson
Publikováno v:
New England Journal of Medicine. 353:1463-1470
background Vibrio parahaemolyticus, the leading cause of seafood-associated gastroenteritis in the United States, typically is associated with the consumption of raw oysters gathered from warm-water estuaries. We describe a recognized outbreak of V.
Autor:
Linda J. Demma, Jennifer H. McQuiston, Christopher D. Paddock, James E. Cheek, David L. Swerdlow, Marc S. Traeger, Joseph Singleton, Michael Levin, Dianna M. Blau, Sherif R. Zaki, Gregory A. Dasch, Marina E. Eremeeva, William L. Nicholson
Publikováno v:
New England Journal of Medicine. 353:587-594
background Rocky Mountain spotted fever is a life-threatening, tick-borne disease caused by Rickettsia rickettsii . This disease is rarely reported in Arizona, and the principal vectors, Dermacentor species ticks, are uncommon in the state. From 2002
Autor:
Mary Grace Stobierski, Lisa N. Pealer, Kimberly Signs, Peter L Page, Jesse L. Goodman, Robert S. Lanciotti, Bruce Newman, Susan L. Stramer, Anthony A. Marfin, Lyle R. Petersen, Mary E. Chamberland, Hema Kapoor
Publikováno v:
New England Journal of Medicine. 349:1236-1245
During the 2002 West Nile virus epidemic in the United States, patients were identified whose West Nile virus illness was temporally associated with the receipt of transfused blood and blood components.Patients with laboratory evidence of recent West
Autor:
Mitsuhiro Kamisago, Sapna D. Sharma, Steven R. DePalma, Scott Solomon, Pankaj Sharma, Barbara McDonough, Leslie Smoot, Mary P. Mullen, Paul K. Woolf, E. Douglas Wigle, J.G. Seidman, John Jarcho, Lawrence R. Shapiro, Christine E. Seidman
Publikováno v:
New England Journal of Medicine. 343:1688-1696
The molecular basis of idiopathic dilated cardiomyopathy, a primary myocardial disorder that results in reduced contractile function, is largely unknown. Some cases of familial dilated cardiomyopathy are caused by mutations in cardiac cytoskeletal pr
An Outbreak of Multidrug-Resistant, Quinolone-ResistantSalmonella entericaSerotype Typhimurium DT104
Autor:
Andreas Petersen, Peter Gerner-Smidt, Jørgen Engberg, Kåre Mølbak, Henrik Caspar Wegener, Jens Munk Ebbesen, Dorte Lau Baggesen, Frank Møller Aarestrup, Kai Frydendahl
Publikováno v:
New England Journal of Medicine. 341:1420-1425
Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenico