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pro vyhledávání: ''
Autor:
Donald B. Kohn, Claire Booth, Kit L. Shaw, Jinhua Xu-Bayford, Elizabeth Garabedian, Valentina Trevisan, Denise A. Carbonaro-Sarracino, Kajal Soni, Dayna Terrazas, Katie Snell, Alan Ikeda, Diego Leon-Rico, Theodore B. Moore, Karen F. Buckland, Ami J. Shah, Kimberly C. Gilmour, Satiro De Oliveira, Christine Rivat, Gay M. Crooks, Natalia Izotova, John Tse, Stuart Adams, Sally Shupien, Hilory Ricketts, Alejandra Davila, Chilenwa Uzowuru, Amalia Icreverzi, Provaboti Barman, Beatriz Campo Fernandez, Roger P. Hollis, Maritess Coronel, Allen Yu, Krista M. Chun, Christian E. Casas, Ruixue Zhang, Serena Arduini, Frances Lynn, Mahesh Kudari, Andrea Spezzi, Marco Zahn, Rene Heimke, Ivan Labik, Roberta Parrott, Rebecca H. Buckley, Lilith Reeves, Kenneth Cornetta, Robert Sokolic, Michael Hershfield, Manfred Schmidt, Fabio Candotti, Harry L. Malech, Adrian J. Thrasher, H. Bobby Gaspar
Publikováno v:
N Engl J Med
The New England journal of medicine, vol 384, iss 21
The New England journal of medicine, vol 384, iss 21
BACKGROUND: Severe combined immunodeficiency due to adenosine deaminase (ADA) deficiency (ADA-SCID) is a rare and life-threatening primary immunodeficiency. METHODS: We treated 50 patients with ADA-SCID (30 in the United States and 20 in the United K
Autor:
Michael E. Wechsler, Elliot Israel, Primal Kaur, Janet M. Griffiths, Christopher E. Brightling, Arnaud Bourdin, Andrew Menzies-gow, Gene L. Colice, Geoffrey Chupp, Gun Almqvist, Jonathan Corren, Karin Bowen, Sandhia Ponnarambil, Åsa Hellqvist
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
New England Journal of Medicine, Massachusetts Medical Society, 2021, 384 (19), pp.1800-1809. ⟨10.1056/NEJMoa2034975⟩
International audience; BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patient
Autor:
Jadambaa Tsolmo, Jutmaan Yanjmaa, Murneren Tunsag, Davaasambuu Ganmaa, Saranjav Ariunzaya, Polyna Khudyakov, Tserenkhuu Enkhtsetseg, Erdenebaatar Sumiya, Dorjnamjil Khulan, Garmaa Gantsetseg, Buyanjargal Uyanga, Ben J. Marais, Ankhbat Munkhzaya, Davaasambuu Enkhmaa, Donna Spiegelman, Baigali Delgerekh, Batbileg Bolortuya, James A Seddon, Ochirbat Batbayar, Bazarsaikhan Amarsaikhan, Adrian R. Martineau, Ganbaatar Erdenetuya, Xin Zhou
Publikováno v:
N Engl J Med
BACKGROUND: Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis. Data from phase 3, randomized, controlled trials of vitamin D supplementation to prevent tuberculosis infection are lacking. METHODS: We randomly assigne
Autor:
Kevan C, Herold, Brian N, Bundy, S Alice, Long, Jeffrey A, Bluestone, Linda A, DiMeglio, Matthew J, Dufort, Stephen E, Gitelman, Peter A, Gottlieb, Jeffrey P, Krischer, Peter S, Linsley, Jennifer B, Marks, Wayne, Moore, Antoinette, Moran, Henry, Rodriguez, William E, Russell, Desmond, Schatz, Jay S, Skyler, Eva, Tsalikian, Diane K, Wherrett, Anette-Gabriele, Ziegler, Carla J, Greenbaum, Stuart, Weinzimer
Publikováno v:
The New England journal of medicine, vol 381, iss 7
BackgroundType 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival. Some interventions have delayed the loss of insulin production in patients with type
Autor:
Timo Wolf, Annemarie Berger, Petra Tiarks-Jungk, Denisa Bojkova, Gerrit Kann, Sebastian Hoehl, Boris Böddinghaus, Markus Eickmann, Maria J G T Vehreschild, Marhild Kortenbusch, Udo Götsch, René Gottschalk, Holger F. Rabenau, Pia Behrens, Frank Naujoks, Antoni Walczok, Jindrich Cinatl, Joscha Schork, Peter J. Neumann, Sandra Ciesek
Publikováno v:
New England Journal of Medicine
The New England Journal of Medicine
The New England Journal of Medicine
Coronavirus in Travelers Returning from China A group of 126 German nationals was evacuated from Wuhan to Frankfurt after screening for symptoms of Covid-19 and was to undergo a 14-day quarantine a...
Autor:
Wei-Jie, Guan, Zheng-Yi, Ni, Yu, Hu, Wen-Hua, Liang, Chun-Quan, Ou, Jian-Xing, He, Lei, Liu, Hong, Shan, Chun-Liang, Lei, David S C, Hui, Bin, Du, Lan-Juan, Li, Guang, Zeng, Kwok-Yung, Yuen, Ru-Chong, Chen, Chun-Li, Tang, Tao, Wang, Ping-Yan, Chen, Jie, Xiang, Shi-Yue, Li, Jin-Lin, Wang, Zi-Jing, Liang, Yi-Xiang, Peng, Li, Wei, Yong, Liu, Ya-Hua, Hu, Peng, Peng, Jian-Ming, Wang, Ji-Yang, Liu, Zhong, Chen, Gang, Li, Zhi-Jian, Zheng, Shao-Qin, Qiu, Jie, Luo, Chang-Jiang, Ye, Shao-Yong, Zhu, Nan-Shan, Zhong
Publikováno v:
New England Journal of Medicine
Perm J
Perm J
Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.We extracted data regarding 1099 patients with lab
Autor:
Diah A Wulandari, Guy B. Marks, Rovina Ruslami, Menonli Adjobimey, Richard Long, Dick Menzies, Thierno Hassane Diallo, Oumou Sow, Kevin Schwartzman, Pei-Zhi Li, Chantal Valiquette, Andrea Benedetti, Lika Apriani, Anete Trajman, M. Gninafon, Kevin Elwood, Karen Hornby, Federica Fregonese, Joseph Obeng Baah, David Zielinski, Philip C. Hill
Publikováno v:
New England Journal of Medicine. 379:454-463
The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life-threatening forms of tuberculosis disease. The current standard treatment - 9 months of isoniazid - has been associated
Autor:
Ostergaard, L., Vesikari, T., Absalon, J., Beeslaar, J., Ward, B. J., Senders, S., Eiden, J. J., Jansen, K. U., Anderson, A. S., York, L. J., Jones, T. R., Harris, S. L., O'Neill, R., Radley, D., Maansson, R., Pregaldien, J. -L., Ginis, J., Staerke, N. B., Perez, J. L., Belle-Isle, J, Elfassi, E, Fredette, P, Garfield, H, Girard, G, Lachance, P, Adamkova, E, Bartonova, E, Drazan, D, Dvorakova, J, Kosina, P, Kyjonkova, A, Ruzkova, R, Vitousova, E, Ahonen, A, Forsten, A, Karppa, T, Kokko, S, Lagerstrom-Tirri, Pm, Simila, Jk, Adelt, T, Behre, U, Schwarz, Tf, Castiglia, P, Esposito, S, Ferrera, G, Icardi, G, Brzostek, J, Hasiec, B, Konior, R, Pejcz, J, Szymanski, H, Witor, A, Faust, Sn, Finn, Ah, Heath, Pt, Pollard, Aj, Altamirano, Dd, Ashley CT Jr, Bader, Gf, Bauer GH Jr, Block SL Jr, Brandon, Dm, Davis, Mg, Devalle, O, Egelhof, Rh, Essink, Bj, Fouch, Bb, Fox, Bp, Franklin, Er, Garscadden, Ag, Goswami, Up, Gregory, Dm, Helman, Ll, Houchin, Vg, Howard, Ce, Johnson, Ad, Johnston WH Jr, Jordan, Ca, Kimmel, Ma, Klein, Tr, Krilov, Lr, Labarbera, Ap, Labuda JM II, Latiolais, Tg, Lello, Lg, Lewis, Dh, Ley, Ja, London, Al, Martin, Ms, Mcguire, Mr, Mosteller, Vc, Naccarato, Tr, Nassim, Cg, Rey, Mr, Robbins, Ra, Rouse, Kg, Schear, Mj, Senders, Sd, Shepard, Js, Simpson, Mw, Slandzicki, Aj, Slechta, Sb, Tetrick, Ll, Varman, M, Wadsworth LT III, Ware, Db, White, Jh, Wisman PP Jr, Blouin, F, Dionne, M, Dzongowski, P, Heaton, Kj, Langley, Jm, O'Mahony, Mfj, Powell, Cn, Ward, Bj, Ostergaard, Lj, Haapaniemi, Tl, Paassilta, M, Volanen, Ik, Lepich, T, Smukalska, E, Tarczon, I, Tetiurka, Bm, Domingo, Jd, Morato, Av, Riera, Mt, Sanchez, Ca, Torrell, Jmr, Blumenau, J, Campbell, Ng, Cervantes, Ja, Douglas, Wg, Ensz, Dj, Ervin, Je, Fiel, Tc, Fragoso, Vg, Fried, Dl, Gleason, Gp, Green, Sl, Haggag, Az, Johnson, Ct, Khaira, Rs, Kirstein, Jl, Kravitz, Ae, Lederman, Sn, Marcadis, I, Miller, Ve, Moretti, Jm, Pragalos, Aa, Puopolo, Ad, Rubino, J, Seiden, Dj, Sharp, Sc, Sheldon, Ea, Shockey, Gr, Smith, Wb, Stringer, Jc, Strout, Cb, Studdard, He, Tresser, Njl.
Publikováno v:
Ostergaard, L, Vesikari, T, Absalon, J, Beeslaar, J, Ward, B J, Senders, S, Eiden, J J, Jansen, K U, Anderson, A S, York, L J, Jones, T R, Harris, S L, O'Neill, R, Radley, D, Maansson, R, Prégaldien, J-L, Ginis, J, Staerke, N B, Perez, J L & B1971009 and B1971016 Trial Investigators 2017, ' A Bivalent Meningococcal B Vaccine in Adolescents and Young Adults ', The New England Journal of Medicine, vol. 377, no. 24, pp. 2349-2362 . https://doi.org/10.1056/NEJMoa1614474
BACKGROUND: MenB-FHbp is a licensed meningococcal B vaccine targeting factor H-binding protein. Two phase 3 studies assessed the safety of the vaccine and its immunogenicity against diverse strains of group B meningococcus.METHODS: We randomly assign
Autor:
Masashi Taki, Katsuyuki Fukutake, Koichiro Yoneyama, Tetsuji Sato, Midori Shima, Naoki Fukazawa, Hideji Hanabusa, Hiroki Yoshida, Tadashi Matsushita, Keiji Nogami
Publikováno v:
New England Journal of Medicine. 374:2044-2053
In patients with severe hemophilia A, standard treatment is regular prophylactic and episodic intravenous infusions of factor VIII. However, these treatments are burdensome, especially for children, and may lead to the formation of anti-factor VIII a
Autor:
Hanna Mandel, Dror Mevorach, Vered Yahalom, Adi Mory, David Azoulay, Omer Weissbrod, Hagit N. Baris, Yaniv Zohar, Lilach Finkel, Adi Tabib, Ron Shaoul, Sarit Peleg, Alina Kurolap, Lilach Bonstein, Orly Eshach-Adiv, Daniella Magen, Elizabeth E. Half, Tamar Paperna, Danit Oz-Levi, Judith Chezar, Tova Hershkovitz, Dan Geiger
Publikováno v:
New England Journal of Medicine. 377:87-89
CD55 (complement decay-accelerating factor) inhibits the alternative and classical arms of the complement pathway. Three patients with protein-losing enteropathy and a genetic variant predicted to result in loss of function of CD55 had a response to