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Publikováno v:
Neurotoxicology and Teratology. 71:32-40
Exposure to organophosphate (OP) compounds leads to behavioral alterations. To determine whether paraoxon has effects on anxiety, anxiety-like behaviors were assessed in paraoxon-exposed rats. Protein expression of glutamate transporters has also bee
Publikováno v:
Neurotoxicology and teratology. 87
Gestational exposure to methylmercury disrupts dopamine-mediated behavior and produces heightened sensitivity to monoamine agonists later in life. This has been reported and replicated following both pre- and post-natal exposure. Impacts of methylmer
Autor:
Sean M. Mooney-Leber, Lisa R. Goldberg, Thomas J. Gould, Philip B. Smith, Laurel R. Seemiller, Dana Zeid
Publikováno v:
Neurotoxicol Teratol
Parental nicotine exposure can impact phenotypes in unexposed offspring. Our laboratory recently published data showing that nicotine reward and hippocampal gene expression involved in stress pathways were perturbed in F1 offspring of male C57BL/6J m
Publikováno v:
Neurotoxicology and Teratology. 61:74-81
The rise in popularity of substituted methcathinones (aka “bath salts”) has increased the focus on their neurotoxic effects. Two commonly abused methcathinones, 3,4-methylenedioxymethcathinone (methylone, MDMC) and 3,4-methylenedioxypyrovalerone
Publikováno v:
Neurotoxicology and Teratology. 61:66-73
Background Developmental exposure to ethanol is recognized to produce long-term neurobehavioral impairment in multiple animal models. However, the molecular mechanisms underlying these deficits remain poorly understood. The present study was undertak
Publikováno v:
Neurotoxicology and Teratology. 61:29-35
This study aims to assess whether geranylgeranylacetone (GGA) could reduce ototoxicity induced by cisplatin through upregulation of not only heat shock protein(HSP)-70, but also HSP-27 and HSP-40, and to study if GGA would reduce cisplatin-induced in
Autor:
Eva Greengrove, Amir H. Rezvani, Andrew B. Hawkey, Hannah White, Edward D. Levin, Susan K. Murphy, Erica Pippen
Publikováno v:
Neurotoxicol Teratol
Studies of intergenerational effects of parental chemical exposure have principally focused on maternal exposure, particularly for studies of adverse neurobehavioral consequences on the offspring. Maternal nicotine exposure has long been known to cau
Autor:
Tahereh Haghpanah, Nima Saeedi, Kobra Bahrampour Juybari, Hamideh Bashiri, Amirhossein Moslemizadeh, Masoumeh Nozari, Azadeh Aminzadeh, Mohammad Khaksari, Gholamreza Sepehri, Seyyed Sajjad Vakili Shahrbabaki, Manzumeh Shamsi Meymandi
Publikováno v:
Neurotoxicology and Teratology. 81:106905
Introduction The present study was designed to clarify the effects of resveratrol (RSV) on social behavioral alterations and nociceptive reactivity in valproic acid (VPA)-induced autistic-like model in female and male rats. Methods Pregnant Wistar ra
Autor:
Deborah A. Cory-Slechta, Marissa Sobolewski, Keith Morris-Schaffer, Carolyn Klocke, Joshua L. Allen, Katherine Conrad
Publikováno v:
Neurotoxicology and Teratology. 56:75-80
Prenatal stress and nutrition are well-known to alter a broad range of physiological systems, notably metabolic, endocrine and neurobehavioral function. Commonly used methods for oral administration of xenobiotics can, by acting as a stressor or alte
Autor:
Beverly A. Huang, Robert J. DeLorenzo, Laxmikant S. Deshpande, Kristin F. Phillips, Robert E. Blair
Publikováno v:
Neurotoxicology and Teratology. 56:81-86
Organophosphate (OP) compounds which include nerve agents and pesticides are considered chemical threat agents. Currently approved antidotes are crucial in limiting OP mediated acute mortality. However, survivors of lethal OP exposure exhibit delayed