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Publikováno v:
Neurotoxicology and Teratology. 69:21-26
Dexmedetomidine is a local anesthetic adjuvant that exerts neuroprotective effects in addition to its sedative and analgesic properties. However, it is not clear whether dexmedetomidine causes any neurotoxicity in neonates. We injected dexmedetomidin
Autor:
Abouzar Shafaghi, Hamideh Bashiri, Manzumeh Shamsi Meymandi, Seyyed Sajjad Vakili Shahrbabaki, Mahmoud Reza Heidari, Azadeh Aminzadeh
Publikováno v:
Neurotoxicology and Teratology. 89:107050
Autism spectrum disorder (ASD) is a complex, behaviorally defined disorder of the immature brain as a result of genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). This syndrome is known for its high prevalence.
Publikováno v:
Neurotoxicology and teratology. 84
Many people undergo procedures requiring general anesthesia each day and adverse cognitive effects have been reported in response to that anesthesia. Postoperative Cognitive Dysfunction (POCD) may occur in as many as 80% of adults during the first po
Publikováno v:
Neurotoxicol Teratol
Chronic prenatal exposure to opioids often causes fetal opioid dependence that leads to neonatal opioid withdrawal syndrome (NOWS) shortly after delivery. Rat models of NOWS often require quantifying neonatal withdrawal behaviors using time-consuming
Autor:
Tahereh Haghpanah, Nima Saeedi, Kobra Bahrampour Juybari, Hamideh Bashiri, Amirhossein Moslemizadeh, Masoumeh Nozari, Azadeh Aminzadeh, Mohammad Khaksari, Gholamreza Sepehri, Seyyed Sajjad Vakili Shahrbabaki, Manzumeh Shamsi Meymandi
Publikováno v:
Neurotoxicology and Teratology. 81:106905
Introduction The present study was designed to clarify the effects of resveratrol (RSV) on social behavioral alterations and nociceptive reactivity in valproic acid (VPA)-induced autistic-like model in female and male rats. Methods Pregnant Wistar ra
Autor:
Vítor Sampaio Minassa, Karla Nívea Sampaio, Igor Simões Assunção Felippe, Rita Gomes Wanderley Pires, Alexandre Cunha, Graziany Leite Moreira Marques, Vanessa Beijamini, Alciene Almeida Siqueira, M.A. Cicilini, T. A. Alarcon, Thallis Coelho da Silva Gramelich
Publikováno v:
Neurotoxicology and teratology. 71
Acute organophosphate (OP) poisoning induces well-known signs of toxicosis related to acetylcholinesterase (AChE) inhibition. However, the relationship between acute OP poisoning and the onset of psychiatric disorders remains unclear. Thus, we invest
Autor:
Jing Li, Yong Zhang, Ming Xiong, Vasanti Tilak, Alex Bekker, Hussain M. Alhashem, Anuradha Patel, Allan Siegel, Jiang-Hong Ye
Publikováno v:
Neurotoxicology and Teratology. 43:51-58
Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive c
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Ivermectin (IVM) is an antiparasitic drug that is widely used in domestic animals. In mammals, IVM acts as a γ-aminobutyric acid (GABA) receptor agonist. This neurotransmitter plays an important role in the regulation of female sexual behavior. The
Autor:
Nathan C. Twaddle, Joseph P. Hanig, Michelle Vanlandingham, Daniel R. Doerge, Becky Divine, John F. Bowyer, Mark S. Levi, Nysia I. George
Publikováno v:
Neurotoxicology and Teratology. 34:253-262
Previous studies focusing on amphetamine (AMPH), methamphetamine (METH) and methylphenidate (MPH) neurotoxicity have almost exclusively been conducted in rodents during the light cycle, which is when most rodents sleep. There are virtually no studies
Autor:
K-L. Catherine Jen, Michael W. Church, J.I. Anumba, Michael Kruger, Brittany R. Adams, D.A. Jackson
Publikováno v:
Neurotoxicology and Teratology. 34:196-205
Antenatal corticosteroid (AC) treatment is given to pregnant women at risk for preterm birth to reduce infant morbidity and mortality by enhancing lung and brain maturation. However, there is no accepted regimen on how frequently AC treatments should