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Publikováno v:
Neurotoxicology
Childhood lead (Pb(2+)) intoxication is a global public health problem best known for producing deficits in learning and poor school performance. Human and preclinical studies have suggested an association between childhood Pb(2+) intoxication and pr
Publikováno v:
NeuroToxicology. 65:248-254
The effect of sarin on the binding parameters (KD & Bmax) of M2 muscarinic acetylcholine receptor (mAChR) was studied 24h and 1 week post exposure. Male & female Sprague-Daweley rats were poisoned with 1XLD50 sarin (80μg/kg, im) followed by treatmen
Autor:
Nastaran Rahimi, Amir Rashidian, Khashayar Afshari, Ghodratollah Panahi, Abbas Norouzi-Javidan, Mina Khalilzadeh, Ahmad Reza Dehpour, Mohammad Reza Hadian, Majid Momeny, Saeed Shakiba, Alireza Abdollahi
Publikováno v:
NeuroToxicology. 67:279-286
Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptor
Publikováno v:
NeuroToxicology. 49:104-113
While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study gr
Autor:
Smaga-Maślanka, Irena, Zaniewska, Magdalena, Gawliński, Dawid, Faron-Górecka, Agata, Szafrański, Przemysław, Cegła, Marek, Filip, Małgorzata
Publikováno v:
Neurotoxicology. 63
The endocannabinoid (eCB) system plays a significant role in the pathophysiology of depression. The potential participation of this system in the mechanism of action of antidepressants has been highlighted in recent years. The aim of this study was t
Autor:
Janelle M. Silvers, Charles F. Mactutus, Rosemarie M. Booze, Marina V. Aksenova, Michael Y. Aksenov
Publikováno v:
NeuroToxicology. 28:1184-1190
Neurotoxic viral proteins released from HIV-infected cells are believed to play a major role in the pathogenesis of the dementia displayed in a significant number of AIDS patients. HIV-1 associated neuropathology severely affects dopaminergic regions
Autor:
Steve C. Fordahl, Christa L. Colyer, Tara L. Weaver, Keith M. Erikson, Joel G. Anderson, Paula T. Cooney
Publikováno v:
Neurotoxicology. 29(6)
Unlike other essential trace elements (e.g., zinc and iron) it is the toxicity of manganese (Mn) that is more common in human populations than its deficiency. Data suggest alterations in dopamine biology may drive the effects associated with Mn neuro
Autor:
Zhice Xu, Caiping Mao, Juanxiu Lv, Lubo Zhang, Hong Zhang, Yujuan Liu, Hui Pengpeng, Liyan Zhu, Feichao Xu
Publikováno v:
Neurotoxicology. 29(4)
Previous studies have suggested that prenatal exposure to nicotine is associated with abnormal development in fetuses, including fetal brain damage. The present study determined the effect of maternal administration of nicotine during different gesta