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Publikováno v:
NeuroToxicology. 88:1-13
Cognitive impairment or "chemobrain" is a troublesome adverse effect which had been increasingly reported by cancer patients after doxorubicin (DOX) chemotherapy. Notably, Hypertension, a very common comorbidity in cancer patients, could pose a great
Publikováno v:
NeuroToxicology. 87:24-29
Opioid overdoses (ODs) are increasing in Mexico's northern border. Because naloxone is usually not available, witnesses inject common salt (NaCl) into a vein of OD victims in an attempt to help them regain consciousness. Despite this widespread pract
Publikováno v:
NeuroToxicology
Following methamphetamine consumption and during abstinence many behavioral consequences emerge (i.e., cognitive deficits, ongoing episodes of psychosis, depression, severe cravings, brain neurotoxicity), which are likely linked to propensity to rela
Autor:
Stephen N. Housley, Dario I. Carrasco, Paul Nardelli, Laura O'Farrell, Timothy C. Cope, Richard K. Noel, Travis M. Rotterman
Publikováno v:
Neurotoxicology
The persisting need for effective clinical treatment of chemotherapy-induced neurotoxicity (CIN) motivates critical evaluation of preclinical models of CIN for their translational relevance. The present study aimed to provide the first quantitative e
Publikováno v:
NeuroToxicology. 85:90-98
Motor dysfunctions are common comorbidities among autism spectrum disorder (ASD) patients. Abnormal cerebellar development throughout critical periods may have an effect on motor functions and result in motor impairments. Vitamin A (VA) plays a cruci
Publikováno v:
NeuroToxicology. 84:208-217
Methamphetamine is used extensively around the world as a psychostimulant. The complications related to methamphetamine include methamphetamine-induced neurotoxicity, mainly involving intraneuronal processes, such as oxidative stress and excitotoxici
Publikováno v:
NeuroToxicology. 74:264-271
Ingestion of the noncompetitive GABAA receptor antagonist tetramethylenedisulfotetramine (TETS) results in arrhythmias, respiratory depression, and life-threatening convulsive status epilepticus. We have previously developed a realistic model of volu
Autor:
Sareh Kermanshahi, Samira Sadr, Majid Motaghinejad, Saghar Keshavarzi, Manijeh Motevalian, Leila Karami
Publikováno v:
NeuroToxicology. 72:74-84
Background Methamphetamine is a neuro-stimulant with neurodegenerative effects, and ambiguous mechanism of action. Metformin is an antidiabetic agent with neuroprotective properties but not fully understood mechanisms. The present study investigated
Autor:
Michael B. Gatch, Michael J. Forster
Publikováno v:
NeuroToxicology. 70:72-79
A new generation of novel cannabinoid compounds have been developed as marijuana substitutes to avoid drug control laws and cannabinoid blood tests. 5F-MDMB-PINACA (also known as 5F-ADB, 5F-ADB-PINACA), MDMB-CHIMICA, MDMB-FUBINACA, ADB-FUBINACA, and
Autor:
Kim Paulson, Derek A. Hamilton, Waylon Weber, Christy M. Magcalas, Nitin Bangera, Robert Raulli, Judith Laney, Andrew P. Gigliotti, Efrain Garcia, Jeffrey D. Lewine, Jacob D. McDonald, Melanie Doyle-Eisele
Publikováno v:
NeuroToxicology. 69:37-46
Rats poisoned with sarin enter into ahyper-cholinergic crisis characterized by excessive salivation, respiratory distress, tremors, seizures, and death. Through the use of rescue medications and an anticonvulsant, death can be avoided in many animals