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Autor:
Lucyna Antkiewicz-Michaluk, Irena Nalepa, Agnieszka Wąsik, Agnieszka Zelek-Molik, Irena Romańska
Publikováno v:
Neurotoxicity Research
Parkinson's disease (PD) is a neurodegenerative disorder of the central nervous system (CNS) caused by a progressive loss of nigrostriatal dopaminergic neurons. Dysfunction of the ubiquitin-proteasome system (UPS) plays an important role in the patho
Autor:
Jolanta Konieczny, Katarzyna Kuter, Anna M. Czarnecka, Tomasz Lenda, Władysław Lasoń, Danuta Jantas, Elżbieta Lorenc-Koci, Helena Domin, Maria Śmiałowska
Publikováno v:
Neurotoxicity Research
A number of studies suggest that the ubiquitin–proteasome system (UPS) impairment may underlie neuronal death in Parkinson’s disease. Celastrol is a neuroprotective agent with anti-inflammatory and antioxidant properties. The aim of this study wa