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Publikováno v:
Neuroscience letters. 756
Adeno-associated virus (AAV)- PHP.B and AAV-PHP.eB (PHP.eB), a capsid variant of AAV serotype 9, efficiently penetrates the mouse blood-brain barrier and predominantly infects neurons. Thus, the PHP.B / PHP.eB capsid and a neuron-specific promoter is
Publikováno v:
Neuroscience letters. 744
Background Spinal cord ischemia/reperfusion injury is a common clinical, pathophysiological phenomenon with complex molecular mechanisms. Currently, there are no therapeutics available to alleviate the same. This study investigates the protective eff
Autor:
Anthony T. Yachnis, Benoit I. Giasson, Grace M. Lloyd, Zachary A. Sorrentino, Sydney A. Labuzan, Stefan Prokop, Dennis W. Dickson, Jorge A. Trejo-Lopez, Cara J. Riffe
Publikováno v:
Neurosci Lett
Transactive response DNA-binding protein of 43 kilodaltons (TDP-43) is a 414 amino acid protein that under physiologic conditions localizes to the nucleus and participates in the regulation of RNA metabolism through two RNA recognition motifs (RRM1 a
Autor:
Hirokazu Hirai, Ayumu Konno, Yasunori Matsuzaki, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada
Publikováno v:
Neuroscience Letters. 665:182-188
Intravenous administration of adeno-associated virus (AAV)-PHP.B, a capsid variant of AAV9 containing seven amino acid insertions, results in a greater permeability of the blood brain barrier (BBB) than standard AAV9 in mice, leading to highly effici
Publikováno v:
Neuroscience Letters. 642:174-178
Background and purpose Multiple sclerosis (MS) is a neurological disease of the central nervous system (CNS) that causes physical and cognitive impairments. IL-7Ra is a key non-MHC gene associated with MS. IL-7Ra is a likely functional candidate for
Autor:
Masaki Ueno, Ryuta Murakami, Masato Mashima, Yoichi Chiba, Koichi Matsumoto, Kenji Kanenishi, Machi Kawauchi, Toshiyuki Hata, Naoya Uemura
Publikováno v:
Neuroscience Letters. 636:90-94
Glucose transporter 8 (GLUT8), a glucose/fructose transporter, has been shown to be expressed in neuronal cells in several brain areas. A recent immunohistochemical study has shown the presence of GLUT8 in the cytoplasm of epithelial cells of the cho
Publikováno v:
Neuroscience Letters. 635:24-32
Elevated plasma levels of homocysteine have been implicated in neurodevelopmental and neurodegenerative disorders in human studies. Although the molecular mechanisms underlying the effects of homocysteine (Hcy) cytotoxicity on the nervous system are
Autor:
M Bazewicz, Dafina Draganova, Catherine Bruyns, Liliane Tenenbaum, Abdel Chtarto, Francois Willermain, V Elmaleh, Maya Makhoul, Laure Caspers
Publikováno v:
Neuroscience letters, vol. 630, pp. 209-215
The purpose of this study was to investigate the in vitro effect of Suppressor Of Cytokine Signaling 1 (SOCS1) overexpression in retinal pigment epithelium (RPE) cells on their activation by pro-inflammatory cytokines IFNγ, TNFα and IL-17. Retinal
Publikováno v:
Neuroscience Letters. 628:207-212
The mitochondria play an important role in apoptotic cell death, and the released cytochrome c from the mitochondria promotes the formation of the apoptosome, which contains cytochrome c, Apaf-1 and caspase-9, resulting in the activation of caspase-9
Publikováno v:
Neuroscience Letters. 622:88-94
NTAK (neural- and thymus-derived activator for ErbB kinases), also known as neuregulin-2 (NRG2), is a member of the epidermal growth factor (EGF) family, which binds directly to ErbB3 and ErbB4, and transactivates ErbB2. NTAK/NRG2 is structurally hom