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Autor:
Kyoung Ja Kwon, Ji Woon Kim, Chan Young Shin, Joo Wan Kim, So Hyun Joo, Mohammad Rakibul Hasan, He-Jin Lee, Seol-Heui Han
Publikováno v:
Neuroscience Letters. 469:352-356
It is increasingly evident that neuroinflammatory response is involved in the pathogenesis of Parkinson's disease. In this study, we examined whether alpha-synuclein, a major components of Lewy body that has been implicated in the modulation of neuro
Publikováno v:
Neuroscience Letters. 463:158-161
The present study explored the effect of curcumin against amyloid beta (Abeta)-induced toxicity on cultured rat primary prefrontal cortical neurons. The results showed that administration of 10 microM of curcumin induced significantly protection agai
Publikováno v:
Neuroscience Letters. 459:123-126
The c-Kit receptor tyrosine kinase regulates the development and differentiation of various progenitor cells. W mutant mice with spontaneous mutations in the c-kit gene show various phenotypes such as anemia, infertility, loss of coat color and mast
Publikováno v:
Neuroscience Letters. 455:93-96
The cellular localization and protein expression level of protein kinase C (PKC)-alpha was examined in pig retina at different ages. Western blot analysis detected PKC-alpha in the retinas of 3-day-old piglets and indicated significantly increased ex
Publikováno v:
Neuroscience Letters. 454(2):129-133
TREK belongs to a subfamily of tandem pore domain K + channels, and consists of three subunits, TREK-1, TREK-2 and TRAAK. We examined the distribution of TREK-1, TREK-2 and TRAAK immunoreactive neurons in rat trigeminal sensory neurons. In the trigem
Publikováno v:
Neuroscience Letters. 449:252-257
We recently cloned the zebrafish neuronal enolase-2 gene and showed that a 12kb eno2 promoter element was sufficient to drive transgene expression widely in CNS neurons in vivo from 48 hours post-fertilization through adulthood. The aim of the presen
Publikováno v:
Neuroscience Letters. 447:78-81
The alpha1A voltage-dependent calcium-channel (Ca(v)2.1) gene, the causative gene for spinocerebellar ataxia type 6 (SCA6), is transcribed into two major mRNA isoforms by alternative splicing at the intron 46-exon 47 boundary. One isoform has a stop
Publikováno v:
Neuroscience Letters. 446:45-50
Mixed neuronal/astrocytic cortical cell cultures of the rat were incubated for 2 or 12 h under normoxic or ischemic conditions. Subsequent flow cytometric analysis with an anti-P2X 7 receptor antibody directed against an extracellular epitope indicat
Autor:
Marina Elizabeth Biedma, Carolina Jaquenod De Giusti, Soledad Collado, Ricardo Martín Gómez, Mirta Schattner, Víctor Romanowski, Roberto Gabriel Pozner, Agustín Enrique Ure
Publikováno v:
Neuroscience Letters. 445:31-35
In a previous study of experimental murine encephalitis induced by Junín virus (JV), an arenavirus, we showed increased expression of iNOS by unidentified cells, concomitant with the astrocyte reaction. The specific inhibition of iNOS was associated
Publikováno v:
Neuroscience Letters. 443:7-11
Viral-vector-mediated gene delivery into Purkinje cells is a promising method for exploring the pathophysiology of the cerebellum; however, it is generally difficult to achieve sufficiently high levels of gene expression in Purkinje cells using viral