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Autor:
Anna A. Kovalenko, Alexander P. Schwarz, Maria V Zakharova, Olga E. Zubareva, Tatiana Y. Postnikova, Aleksey V. Zaitsev
Publikováno v:
Neuroscience. 468:1-15
Acute seizures can severely affect brain function and development. However, the underlying pathophysiological mechanisms are still poorly understood. Disturbances of the glutamatergic system are considered one of the critical mechanisms of neurologic
Autor:
Hasan Alhaddad, Terry D. Hinds, Richard L. Bell, Darren M. Gordon, Youssef Sari, Erin Jarvis, Zachary A. Kipp
Publikováno v:
Neuroscience
Evidence suggests the hypothalamic–pituitary–adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to ca
Autor:
Ali Akbar Owji, Mohammad Ali Takhshid, Farideh Jalali Mashayekhi, Zahra Khoshdel, Somayeh Ahmadpour Jirandeh, Shahla Shojaei
Publikováno v:
Neuroscience. 422:54-64
The pancreatic peptide, Amylin (AMY), reportedly affects nociception in rodents. Here, we investigated the potential effect of AMY on the tolerance to morphine and on the expression of BDNF at both levels of protein and RNA in the lumbar spinal cord
Autor:
Aaron J. Salisbury, Michael Leary, Jean Lud Cadet, Michael T. McCoy, Christopher A. Blackwood
Publikováno v:
Neuroscience
Addiction to prescribed opioids including oxycodone has reached tragic levels. Herein, we investigated the relevance of fibroblast growth factors (FGFs) and immediate early genes (IEGs) to withdrawal-induced incubation of drug craving following escal
Autor:
Yan Fan, Meng-Yang Zhu, Katalin Szebeni, Craig A. Stockmeier, Attila Szebeni, Muhammad U. Raza, Ping Chen, Gregory A. Ordway
Publikováno v:
Neuroscience. 393:123-137
Phox2a and Phox2b are two homeodomain transcription factors playing a pivotal role in the development of noradrenergic neurons during the embryonic period. However, their expression and function in adulthood remain to be elucidated. Using human postm
Autor:
Edina Szucs, Ewelina Rojewska, Barbara Przewlocka, Joanna Mika, Agnieszka Wawrzczak-Bargiela, Sándor Benyhe, Joanna Starnowska, Ryszard Przewlocki
Publikováno v:
Neuroscience. 390:293-302
Clinical studies have reported lower effectivity of opioid drugs in therapy of neuropathic pain. Therefore, to determine the changes in endogenous opioid systems in this pain more precisely, we have studied the changes in the pain-related behavior on
Publikováno v:
Neuroscience. 388:448-459
Anxiety disorder is a major psychiatric disorder characterized by fear, worry, and excessive rumination. However, the molecular mechanisms underlying neural plasticity and anxiety remain unclear. Here, we utilized a mouse model of anxiety-like behavi
Autor:
Yu Wan, Zheqiong Yang, Xianfei Xie, Jiang Yue, Furong Zhang, Jie Li, Shufang Na, Juan Wu, Ke Li
Publikováno v:
Neuroscience. 379:115-125
Brain CYP2D is responsible for the synthesis of endogenous neurotransmitters such as dopamine and serotonin. This study is to investigate the effects of cerebral CYP2D on mouse behavior and the mechanism whereby growth hormone regulates brain CYP2D.
Publikováno v:
Neuroscience. 379:126-141
Parkinson's disease (PD) related to homozygous mutations in the Pink1 gene is associated with nigrostriatal dopamine depletion and a wide range of sensorimotor deficits. In humans and animal models of PD, not all sensorimotor deficits are levodopa-re
Autor:
Cristiano Mendes-da-Silva, Simone Ferreira Lemes, Marciane Milanski, Camilla M. Souza, Tanyara Baliani Payolla, Milena Diorio Versutti, Adriana Souza Torsoni, Marcio Alberto Torsoni, Anelise C. P. Souza, Albina F. Ramalho
Publikováno v:
Neuroscience. 371:1-15
Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signaling activation, leading to repression of proneural factors