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Autor:
Jennifer Hernandez, Edward J. Wagner, Isabella Vahrson, Sarah Sayers, Lynnea Perez, Nikki Le, Cassandra Gastelum
Publikováno v:
Neuroscience
Pituitary adenylate cyclase-activating polypeptide (PACAP) binds to PACAP-specific (PAC1) receptors in multiple hypothalamic areas, especially those regulating energy balance. PACAP neurons in the ventromedial nucleus (VMN) exert anorexigenic effects
Autor:
Jolie Danial, Cecilia Bull, Olena Prykhodko, Dilip Kumar Malipatlolla, Marie Kalm, Rukaya Naama Walid, Spandana Masuram, Yohanna Eriksson, Sravani Devarakonda, Rita Grandér, Gunnar Steineck, Margareta Nyman, Ana Rascón, Ella Ittner, H. Georg Kuhn, Fei Sjöberg, Piyush M. Patel
Publikováno v:
Neuroscience. 475:137-147
We sought to determine whether radiation to the colorectum had an impact on parameters of hippocampal neurogenesis and, if so, whether it could be modulated by a fiber-rich diet. Male C57BL/6J mice were fed a diet containing bioprocessed oat bran or
Autor:
Noora Puhakka, Asla Pitkänen, Johanna Hiltunen, Anssi Lipponen, Günther Sperk, Xavier Ekolle Ndode-Ekane, Meinrad Drexel
Publikováno v:
Neuroscience. 475:52-72
Traumatic brain injury (TBI) causes 10–20% of structural epilepsy, with seizures typically originating in the cortex. Alterations in the neuronal microcircuits in the cortical epileptogenic zone, however, are poorly understood. Here, we assessed TB
Publikováno v:
Neuroscience. 472:157-166
Status epilepticus (SE) is a life-threatening neurological disorder that causes neuronal death and glial activation. Studies have explained the clinical side effects and lack of effectiveness of neurological disorder treatments based on sex-related d
Autor:
Koichi Iwata, Ikuko Shibuta, Naoto Taguchi, Hitoshi Sato, Akihiko Furukawa, Masatoshi Ando, Takanobu Inada, Eri Oshima, Hiromasa Tsuda, Tatsuo Shirota, Jo Otsuji, Suzuro Hitomi, Masamichi Shinoda, Yoshinori Hayashi
Publikováno v:
Neuroscience. 468:43-52
Sensory disturbance in the orofacial region owing to trigeminal nerve injury is caused by dental treatment or accident. Commercially available therapeutics are ineffective for the treatment of sensory disturbance. Additionally, the therapeutic effect
Autor:
Anna A. Kovalenko, Alexander P. Schwarz, Maria V Zakharova, Olga E. Zubareva, Tatiana Y. Postnikova, Aleksey V. Zaitsev
Publikováno v:
Neuroscience. 468:1-15
Acute seizures can severely affect brain function and development. However, the underlying pathophysiological mechanisms are still poorly understood. Disturbances of the glutamatergic system are considered one of the critical mechanisms of neurologic
Publikováno v:
Neuroscience. 466:248-257
The present study aimed to assess the impact of transcranial direct current stimulation (tDCS) on different domains of inhibitory control in children with mild or severe ADHD symptoms. Twenty-four children with ADHD, in two groups with severe and mil
Autor:
Kaihui Nan, Mei Chen, Haochen Jin, Mingna Xu, Zan Gong, Haijun Qiu, Bo Liu, Si Zhang, Wencan Wu, Hui Zhu
Publikováno v:
Neuroscience. 465:71-84
In adult mammals, axon regeneration is limited within the lesion site after injury to the optic nerve. Changes in the microenvironment of lesion sites play an important role in retinal ganglion cells (RGCs) axon regeneration along with other intrinsi
Autor:
Claire E. Manning, Vedrana Bali, Shantée N. Ayala Rosario, Minerva Rodriguez, Michelle S. Mazei-Robison, Sarah C. Simmons, Marie A. Doyle, Ali R. Stark, Alfred J. Robison
Publikováno v:
Neuroscience
Despite the high prevalence of major depressive disorder (MDD), understanding of the biological underpinnings remains limited. Rodent models suggest that changes in activity and output of dopamine (DA) neurons in the ventral tegmental area (VTA) are
Publikováno v:
Neuroscience. 463:216-226
Objective: Cognitive dysfunction often accompanies diabetes. Both hypoglycemia and hyperglycemia cause cognitive dysfunctions. However, the underlying pathophysiology remains unclear. Recent evidence show that ferroptosis primarily triggers nerve cel